Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CONTINUOUS-INFUSION VERSUS INTERMITTENT SHORT INFUSION OF METOCLOPRAMIDE FOR CISPLATIN-INDUCED ACUTE EMESIS
Autore:
SAITO H; SHIMOKATA K; YAMORI S; KAJITA M; NIIMI T;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 1,SHOWA KU,65 TSURUMAI NAGOYA AICHI 466 JAPAN NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 1,SHOWA KU NAGOYA AICHI 466 JAPAN CHUBU NATL HOSP,DEPT MED OBU AICHI JAPAN CHUBU NATL HOSP,DEPT SURG OBU AICHI JAPAN
Titolo Testata:
American journal of clinical oncology
fascicolo: 5, volume: 17, anno: 1994,
pagine: 422 - 426
SICI:
0277-3732(1994)17:5<422:CVISIO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE METOCLOPRAMIDE; CANCER-CHEMOTHERAPY; RANDOMIZED TRIAL; DOUBLE-BLIND; PREVENTION; DIPHENHYDRAMINE; DEXAMETHASONE; EFFICACY; NAUSEA;
Keywords:
CISPLATIN; ACUTE NAUSEA AND VOMITING; METOCLOPRAMIDE; CONTINUOUS INFUSION; INTERMITTENT SHORT INFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
H. Saito et al., "CONTINUOUS-INFUSION VERSUS INTERMITTENT SHORT INFUSION OF METOCLOPRAMIDE FOR CISPLATIN-INDUCED ACUTE EMESIS", American journal of clinical oncology, 17(5), 1994, pp. 422-426

Abstract

Metoclopramide is an active antiemetic against cisplatin-induced acute emesis. However, the optimal administration method (continuous infusion versus intermittent short infusion) for metoclopramide has not yetbeen clearly defined. We have conducted a randomized crossover study to compare the antiemetic efficacy of continuous infusion of metoclopramide with that of intermittent short infusion of metoclopramide in 54evaluable patients. Patients were stratified according to sex and were randomized to receive either a continuous-infusion regimen (regimen A) or an intermittent-short infusion regimen (regimen B). Patients were switched to the alternate therapy in the second course. In regimen A, metoclopramide at 3 mg/kg i.v. was given before cisplatin, and then metoclopramide at 4 mg/kg was infused intravenously over 7.5 hours. Inregimen B, metoclopramide at 3 mg/kg i.v. was followed by 2 mg/kg i.v. for two doses. Dexamethasone and diphenhydramine were given intravenously in both regimens. There was no significant difference between two regimens in their ability to prevent emesis. Complete protection (noepisode of emesis) and major protection (less than or equal to 2 episodes of emesis), respectively, were obtained by 67% (95% confidence interval: 53-79%) and 85% (95% confidence interval: 73-93%) of all patients given regimen A and by 59% (95% confidence interval: 45-72%) and 81% (95% confidence interval: 68-91%) of those given regimen B. The tworegimens were also equally effective in controlling nausea. However, male patients showed better control of nausea and vomiting than did female patients, regardless of treatment regimen. Toxicity was mild in both regimens and was well tolerated. Our findings indicate that both continuous-infusion metoclopramide and intermittent-short infusion metoclopramide are effective in controlling cisplatin-induced acute nauseaand vomiting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:24:52