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Titolo:
COMPARTMENTALIZED CYTOKINE PRODUCTION WITHIN THE HUMAN LUNG IN UNILATERAL PNEUMONIA
Autore:
DEHOUX MS; BOUTTEN A; OSTINELLI J; SETA N; DOMBRET MC; CRESTANI B; DESCHENES M; TROUILLET JL; AUBIER M;
Indirizzi:
HOP BICHAT,SERV PNEUMOL,46 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE HOP BICHAT,SERV PNEUMOL F-75877 PARIS 18 FRANCE HOP BICHAT,SERV BIOCHIM A PARIS FRANCE HOP BICHAT,INSERM,U408 PARIS FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 3, volume: 150, anno: 1994,
pagine: 710 - 716
SICI:
1073-449X(1994)150:3<710:CCPWTH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; RESPIRATORY-DISTRESS-SYNDROME; FACTOR-ALPHA; GENE-EXPRESSION; POLYMORPHONUCLEAR NEUTROPHILS; INFLAMMATORY RESPONSE; PULMONARY INFECTIONS; ENDOTOXIN TOLERANCE; INTERLEUKIN-1; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Dehoux et al., "COMPARTMENTALIZED CYTOKINE PRODUCTION WITHIN THE HUMAN LUNG IN UNILATERAL PNEUMONIA", American journal of respiratory and critical care medicine, 150(3), 1994, pp. 710-716

Abstract

The in situ inflammatory response developing in the human lung duringa localized bacterial infection was studied in 15 patients with unilateral community-acquired pneumonia (CAP). The local response in the involved lung was compared with that in the contralateral, noninvolved lung as well as with the systemic blood response. Eight healthy volunteers served as control subjects. Concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6(IL-6) were measured by ELISA in bronchoalveolar lavage (BAL) fluids (n = 15), serum (n = 15), and alveolar macrophage and monocyte culturesupernatants (n = 8). The concentrations of TNF-alpha, IL-beta and IL-6 in BAL fluid were significantly higher in the involved lung than inthe paired noninvolved lung (p less than or equal to 0.01) or in healthy subjects (p less than or equal to 0.02, p less than or equal to 0.01, and p less than or equal to 0.001, respectively). Serum IL-6 concentrations were higher in patients than in control subjects, whereas IL-1 beta and TNF-alpha concentrations did not differ in the two groups. Alveolar macrophages from the involved lung spontaneously released higher concentrations of IL-1 beta, IL-6, and TNF-alpha (p less than or equal to 0.05) than did macrophages from the noninvolved lung, which served as controls. However, macrophages were hyporesponsive in terms of cytokine production to further stimulation by lipopolysaccharide (LPS) in the noninvolved and involved lung compared with controls, whereas peripheral blood monocytes were not. Our results suggest that duringunilateral CAP, the inflammatory response is compartmentalized withinthe human lung and limited to the site of infection with respect to the production of TNF-alpha, IL-1 beta, and IL-6.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:55:42