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Titolo:
METHOTREXATE IN STEROID-DEPENDENT ASTHMA - LONG-TERM RESULTS
Autore:
SHINER RJ; KATZ I; SHULIMZON T; SILKOFF P; BENZARAY S;
Indirizzi:
CHAIM SHEBA MED CTR,INST RESP MED,DEPT CLIN RESP PHYSIOL IL-52621 TELHASHOMER ISRAEL
Titolo Testata:
Allergy
fascicolo: 7, volume: 49, anno: 1994,
pagine: 565 - 568
SICI:
0105-4538(1994)49:7<565:MISA-L>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; PNEUMONITIS; THERAPY;
Keywords:
ASTHMA; METHOTREXATE; PULMONARY FIBROSIS; TOXIC HEPATITIS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Shiner et al., "METHOTREXATE IN STEROID-DEPENDENT ASTHMA - LONG-TERM RESULTS", Allergy, 49(7), 1994, pp. 565-568

Abstract

Treatment of 21 steroid-dependent asthmatic patients with methotrexate (MTX) 15 mg/week was prospectively evaluated for a mean of 14.7 (SD 3.7) months. Before MTX, therapy consisted of a mean prednisone dose of 16.6 (SD 9.2) mg, in addition to inhaled beclomethasone/budesonide (mean daily dose 1157 (SD 330) mu g) and bronchodilators. Thirteen patients were weaned from all regular systemic steroid therapy, a 50% or more reduction was achieved in four patients, and a less than 50% reduction in four patients. Abnormal liver function tests were noted in sixof the 21 patients; this resolved despite continuation of MTX in five. In one patient, MTX was stopped because of symptoms as well as a fivefold rise in serum transaminases, and a speedy resolution was noted. Gastrointestinal side-effects were reported in six patients but were resolved in five with intramuscular MTX. There were no hematologic or pulmonary complications. We conclude that MTX appears to be both safe and efficacious as a steroid-sparing agent in most steroid-dependent asthmatic patients when taken over a long period.

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Documento generato il 28/02/20 alle ore 12:57:07