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Titolo:
INHIBITORY EFFECTS OF PROSTACYCLIN ANALOG, TFC-132, ON AORTIC NEOINTIMAL THICKENING IN-VIVO AND SMOOTH-MUSCLE CELL-PROLIFERATION IN-VITRO
Autore:
ASADA Y; KISANUKI A; HATAKEYAMA K; TAKAHAMA S; KOYAMA T; KUROZUMI S; SUMIYOSHI A;
Indirizzi:
MIYAZAKI MED COLL,DEPT PATHOL 1,5200 KIHARA MIYAZAKI 88916 JAPAN TEIJIN INST BIOMED RES HINO TOKYO 191 JAPAN
Titolo Testata:
Prostaglandins, leukotrienes and essential fatty acids
fascicolo: 4, volume: 51, anno: 1994,
pagine: 245 - 248
SICI:
0952-3278(1994)51:4<245:IEOPAT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY ANGIOPLASTY; DNA-SYNTHESIS; RESTENOSIS; PROSTAGLANDIN-I2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
Y. Asada et al., "INHIBITORY EFFECTS OF PROSTACYCLIN ANALOG, TFC-132, ON AORTIC NEOINTIMAL THICKENING IN-VIVO AND SMOOTH-MUSCLE CELL-PROLIFERATION IN-VITRO", Prostaglandins, leukotrienes and essential fatty acids, 51(4), 1994, pp. 245-248

Abstract

Effects of a new prostacyclin analogue, TFC-132, on neointimal thickening following intimal mechanical injury and on the proliferation of cultured aortic smooth muscle cells (SMCs) were studied. The intimal injury was induced by indwelling of polyethylene tubing for 24 h in the rabbit aorta. Rabbits mere killed 10 days after drawing out the tubing. TFC-132 (0.6 mg/kg or 1.2 mg/kg) was given orally at 8-h intervals through the experiment. The serum concentrations of the analogue rose significantly 1 and 2h after administration. The mean intimal thickening in the TFC-132 treated groups was significantly thinner than in the control one. Human aortic SMCs were cultured and H-3-thymidine incorporation into DNA (DNA synthesis) was measured at the varying concentrations of TFC-132. The analogue inhibited DNA synthesis of cultured SMCsat 10(-6) and 10(-5) M. These data indicate that a nem prostacyclin analogue, TFC-132, has an inhibitory effect on the neointimal thickening after intimal injury and on the aortic SMC proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 09:41:03