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Titolo:
GLUCOSE-TRANSPORTER ISOFORM EXPRESSION IN HUNTINGTONS-DISEASE BRAIN
Autore:
GAMBERINO WC; BRENNAN WA;
Indirizzi:
PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,POB 850 HERSHEY PA 17033 PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL HERSHEY PA 17033
Titolo Testata:
Journal of neurochemistry
fascicolo: 4, volume: 63, anno: 1994,
pagine: 1392 - 1397
SICI:
0022-3042(1994)63:4<1392:GIEIHB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALZHEIMERS-DISEASE; INSULIN-RECEPTOR; PRIMARY CULTURES; RISK; METABOLISM; PROTEIN; BARRIER; FETAL; LIVER;
Keywords:
HUNTINGTONS DISEASE; GLUCOSE TRANSPORTER; NEURON LOSS; GLIOSIS; GLUT1; GLUT3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
W.C. Gamberino e W.A. Brennan, "GLUCOSE-TRANSPORTER ISOFORM EXPRESSION IN HUNTINGTONS-DISEASE BRAIN", Journal of neurochemistry, 63(4), 1994, pp. 1392-1397

Abstract

Several reports have suggested a characteristic decrease in glucose use in the striatum of patients with Huntington's disease (HD) may contribute to the cellular atrophy of the caudate and putamen. We examinedthe expression of the two major glucose transporter isoforms of brain, GLUT1 and GLUT3. GLUT1 is found largely in capillary endothelial cells and to a lesser extent in the brain parenchyma, whereas GLUT3 is localized primarily in neurons. Membranes prepared from postmortem samples of HD caudate and cortex and non-HD caudate and cortex were separated on 10% sodium dodecyl sulfate-polyacrylamide gels and probed with antisera to GLUT1 and GLUT3 by western blotting. Compared with controls, GLUT1 and GLUT3 transporter expression in caudate was decreased by three- and fourfold, respectively, in grade 3 of the disease. At earlier stages (grade 1), there was no significant difference in the expression of the two transporter isoforms compared with nondiseased controls. It is surprising that despite a substantial increase in glial fibrillary acidic protein immunoreactivity (an indicator of the extent of gliosis), glucose transporter expression was diminished significantly inHD caudate. The results suggest in the absence of a significant number of neurons, as in grade 3, glial cell GLUT1 and GLUT3 expression is down-regulated, perhaps reflecting the decreased metabolic demand of this brain region in HD.

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Documento generato il 03/04/20 alle ore 05:45:20