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Titolo:
IDENTIFICATION OF A SET OF YEAST GENES-CODING FOR A NOVEL FAMILY OF PUTATIVE ATPASES WITH HIGH SIMILARITY TO CONSTITUENTS OF THE 26S PROTEASE COMPLEX
Autore:
SCHNALL R; MANNHAUPT G; STUCKA R; TAUER R; EHNLE S; SCHWARZLOSE C; VETTER I; FELDMANN H;
Indirizzi:
UNIV MUNICH,INST PHYSIOL CHEM PHYS BIOCHEM & ZELLBIOL,SCHILLERSTR 44 D-80336 MUNICH GERMANY UNIV MUNICH,INST PHYSIOL CHEM PHYS BIOCHEM & ZELLBIOL D-80336 MUNICH GERMANY
Titolo Testata:
Yeast
fascicolo: 9, volume: 10, anno: 1994,
pagine: 1141 - 1155
SICI:
0749-503X(1994)10:9<1141:IOASOY>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAT-BINDING-PROTEIN; SACCHAROMYCES-CEREVISIAE; MEDIATED TRANSACTIVATION; 26-S PROTEASE; RNA HELICASES; MEMBER; EXPRESSION; ATP; DNA; TRANSFORMATION;
Keywords:
MULTIGENE FAMILY; ATPASES; PROTEASOME; SACCHAROMYCES-CEREVISIAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
R. Schnall et al., "IDENTIFICATION OF A SET OF YEAST GENES-CODING FOR A NOVEL FAMILY OF PUTATIVE ATPASES WITH HIGH SIMILARITY TO CONSTITUENTS OF THE 26S PROTEASE COMPLEX", Yeast, 10(9), 1994, pp. 1141-1155

Abstract

There is accumulating evidence for a large, highly conserved gene family of putative ATPases. We have identified 12 different members of this novel gene family (the YTA family) in yeast and determined the nucleotide sequences of nine of these genes. All of the putative gene products are characterized by the presence of a highly conserved domain of300 amino acids containing specialized forms of the A and B boxes of ATPases. YTA1, YTA2, YTA3 and YTA5 exhibit significant similarity to proteins involved in human immunodeficiency virus Tat-mediated gene expression but more significantly to subunits of the human 26S proteasome. YTA1 and YTA2 are essential genes in yeast. Remarkably, the cDNA of human TBP-1 can compensate for the loss of YTA1. Preliminary experiments indicate that YTA1 is a component of the 26S protease complex from yeast. Our findings lead us to propose that YTA1, YTA2, YTA3 and YTA5 function as regulatory subunits of the yeast 26S proteasome. YTA10, YTA11 and YTA12 share significant homology with the Escherchia coli FtsHprotein, and together with YTA4 and YTA6 may constitute a separate subclass within this family of putative ATPases.

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Documento generato il 02/10/20 alle ore 01:36:31