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Titolo:
LONG-TERM ORAL-ADMINISTRATION OF L-ARGININE REDUCES INTIMAL THICKENING AND ENHANCES NEOENDOTHELIUM-DEPENDENT ACETYLCHOLINE-INDUCED RELAXATION AFTER ARTERIAL INJURY
Autore:
HAMON M; VALLET B; BAUTERS C; WERNERT N; MCFADDEN EP; LABLANCHE JM; DUPUIS B; BERTRAND ME;
Indirizzi:
HOP CARDIOL LILLE,SERV CARDIOL & HEMODYNAM B,BLVD PROF J LECLERCQ F-59037 LILLE FRANCE UNIV LILLE,DEPT CARDIOL LILLE FRANCE UNIV LILLE,DEPT PHARMACOL LILLE FRANCE UNIV LILLE,DEPT PATHOL LILLE FRANCE
Titolo Testata:
Circulation
fascicolo: 3, volume: 90, anno: 1994,
pagine: 1357 - 1362
SICI:
0009-7322(1994)90:3<1357:LOOLRI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CAROTID ARTERIES; NITRIC-OXIDE RELEASE; SMOOTH-MUSCLE; HYPERCHOLESTEROLEMIC RABBIT; REGENERATED ENDOTHELIUM; CORONARY ANGIOPLASTY; MECHANISMS; CELLS; PROLIFERATION; PATHOGENESIS;
Keywords:
ENDOTHELIUM-DERIVED FACTORS; BALLOON; ACETYLCHOLINE; ENDOTHELIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Hamon et al., "LONG-TERM ORAL-ADMINISTRATION OF L-ARGININE REDUCES INTIMAL THICKENING AND ENHANCES NEOENDOTHELIUM-DEPENDENT ACETYLCHOLINE-INDUCED RELAXATION AFTER ARTERIAL INJURY", Circulation, 90(3), 1994, pp. 1357-1362

Abstract

Background Nitric oxide (NO), in addition to its potent vasorelaxant properties, may participate in growth regulation of cultured smooth muscle cells. It was recently demonstrated that in vivo endothelial injury induces the production of NO from L-arginine in the arterial wall. Methods and Results We studied the effects of long-term administrationof L-arginine, the precursor of NO, on neointimal thickening and on neoendothelium-dependent vasorelaxation 4 weeks after balloon denudation of normocholesterolemic rabbit iliac arteries. Rabbits were fed witheither a standard diet or a diet supplemented with L-arginine (2.25%)in their drinking water 3 days before and during 4 weeks after balloon denudation. The effectiveness of L-arginine supplementation was confirmed by measurement of plasma arginine levels. L-Arginine had no effect on hemodynamic parameters. All animals were killed 4 weeks after balloon denudation, and a digital histomorphometric analysis of three serial nonconsecutive histological cross sections per iliac artery was performed. Intimal thickening was reduced (P<.05) from 0.43+/-0.08 (SE)mm(2) in controls (n=8) to 0.24+/-0.02 mm(2) in treated animals (n=8). Ten animals (n=5 in each group) were used for in vitro vasoreactivity assessment 4 weeks after balloon denudation. Neoendothelium-dependent acetylcholine-induced relaxation (10(-8) mol/L to 3.10(-5) mol/L) intreated animals (Emax=-24.1+/-5.5%) was significantly greater than incontrols (Emax=-8.9+/-2.2%). Endothelium-independent relaxation did not differ between groups (Emax=-58.1+/-6.5% in L-arginine-supplementedanimals versus -52.9+/-6.8% in controls). Conclusions Our results demonstrate that L-arginine, a precursor of NO, reduces neointimal thickening after balloon denudation and improves neoendothelial-dependent acetylcholine-induced relaxation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:39:41