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Titolo:
THE EFFECT OF SHORT-TERM ADMINISTRATION OF THEOPHYLLINE ON ERYTHROPOIETIN LEVELS IN HEALTHY-ADULTS
Autore:
SHARMA R; BLAKE K; MURPHY S; CLANCY M; DUCKWORTH L; PITEL P; LAWRENCE S;
Indirizzi:
UNIV FLORIDA,HLTH SCI CTR,DEPT PEDIAT,DIV NEONATOL,653-1 W 8TH ST JACKSONVILLE FL 32209 NEMOURS CHILDRENS CLIN,DEPT RES JACKSONVILLE FL 00000
Titolo Testata:
Pharmacotherapy
fascicolo: 2, volume: 14, anno: 1994,
pagine: 215 - 218
SICI:
0277-0008(1994)14:2<215:TEOSAO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE ERYTHROPOIETIN; SERUM; PREMATURITY; MODULATION; OXYGEN; ANEMIA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R. Sharma et al., "THE EFFECT OF SHORT-TERM ADMINISTRATION OF THEOPHYLLINE ON ERYTHROPOIETIN LEVELS IN HEALTHY-ADULTS", Pharmacotherapy, 14(2), 1994, pp. 215-218

Abstract

A previous study demonstrated suppression of erythropoietin production in patients treated with long-term theophylline. This effect could exacerbate anemia of prematurity in neonates receiving this drug for apnea of prematurity. In this pilot project we evaluated the effect of short-term theophylline administration on serum erythropoietin in healthy adults. Six subjects were given a bolus followed by a continuous infusion of theophylline targeted to achieve a serum level of at least 10 mug/ml, followed by oral theophylline for 36 hours. Serum erythropoietin and theophylline levels were measured before, during, and after drug infusion. Complete hemograms were performed before and after completion of the infusion. No significant changes in serum erythropoietin levels were seen at any time (F=1.57, p=0.12). Hematologic values alsoremained unaltered. We conclude that short-term administration of theophylline is unlikely to have any effect on serum erythropoietin levels in healthy adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:58:56