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Titolo:
ULTRAVIOLET LIGHT-INDUCED KERATINOCYTE APOPTOSIS - A POTENTIAL MECHANISM FOR THE INDUCTION OF SKIN-LESIONS AND AUTOANTIBODY PRODUCTION IN LE
Autore:
CASCIOLAROSEN L; ROSEN A;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT DERMATOL,720 RUTLAND AVE,ROOM 1055 BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT MED BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT ANAT & CELL BIOL BALTIMORE MD 21205
Titolo Testata:
Lupus
fascicolo: 2, volume: 6, anno: 1997,
pagine: 175 - 180
SICI:
0961-2033(1997)6:2<175:ULKA-A>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; ICE-LIKE PROTEASES; CELL-DEATH; POLY(ADP-RIBOSE) POLYMERASE; ESCAPE TOLERANCE; NUCLEAR ANTIGENS; T-CELLS; BINDING; ANTIBODIES; PROTEIN;
Keywords:
LUPUS; KERATINOCYTES; APOPTOSIS; AUTOANTIBODY; ICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
L. Casciolarosen e A. Rosen, "ULTRAVIOLET LIGHT-INDUCED KERATINOCYTE APOPTOSIS - A POTENTIAL MECHANISM FOR THE INDUCTION OF SKIN-LESIONS AND AUTOANTIBODY PRODUCTION IN LE", Lupus, 6(2), 1997, pp. 175-180

Abstract

Systemic lupus erythematosus (SLE) is a prototype systemic autoimmunedisease which is characterized clinically by pleiotropy and periodicity. The immune features which accompany the characteristic flares of the disease have strongly suggested that the autoimmune response is driven by self antigen, and is T cell-dependent. These features have prompted the search for potential initiating process(es) which induce the release of self-antigens in a form which causes T cell tolerance to those self molecules to be broken. We review here several recent observations which implicate apoptotic cells as an important potential sourceof clustered and concentrated autoantigens in SLE, and present our current model whereby the novel autoantigen fragments generated in apoptotic surface blebs initiate and drive the autoimmune response in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:46:30