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Titolo:
RENAL CYSTS IN TRANSGENIC MICE EXPRESSING TRANSFORMING GROWTH-FACTOR-ALPHA
Autore:
LOWDEN DA; LINDEMANN GW; MERLINO G; BARASH BD; CALVET JP; GATTONE VH;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL,3901 RAINBOW BLVD KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL KANSAS CITY KS 00000 UNIV KANSAS,KIDNEY & UROL RES CTR KANSAS CITY KS 00000 NCI,MOLEC BIOL LAB BETHESDA MD 20892
Titolo Testata:
The Journal of laboratory and clinical medicine
fascicolo: 3, volume: 124, anno: 1994,
pagine: 386 - 394
SICI:
0022-2143(1994)124:3<386:RCITME>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC KIDNEY-DISEASE; GENE-EXPRESSION; FACTOR RECEPTOR; EARLY REGION; TGF-ALPHA; MOUSE; GLAND; CELLS; BETA; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Lowden et al., "RENAL CYSTS IN TRANSGENIC MICE EXPRESSING TRANSFORMING GROWTH-FACTOR-ALPHA", The Journal of laboratory and clinical medicine, 124(3), 1994, pp. 386-394

Abstract

Transforming growth factor-alpha (TGF-alpha) is a member of the epidermal growth factor (EGF) family of proteins and, like EGF, elicits itscellular function by binding to the EGF receptor. EGF stimulation mayhave a role in several normal and pathologic processes in the kidney,and EGF has been implicated in the development of renal cysts in vitro and in human autosomal dominant polycystic kidney disease. We soughtto determine whether renal expression of an EGF-like protein (TGF-alpha) could lead to the formation of renal cysts in vivo. We examined morphologic alterations to the normal kidney caused by renal expression of a TGF-alpha transgene linked to a mouse metallothionein promoter stably integrated into the genome of the CD1 mouse. TGF-alpha transgene expression was induced with exogenous zinc treatment starting at 4 weeks of age, and mice were killed at 8 weeks of age. The transgene was expressed at higher levels in female transgenic mice than in male transgenic mice. The augmented expression of the TGF-alpha transgene in females was associated with increased renal size and the development of renal epithelial cysts. Both male and female mice exhibited increases in glomerular size and mesangial volume density. These results provide evidence that stimulation by an endogenous EGF-like protein can lead to renal enlargement, glomerular mesangial expansion, and renal cyst formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:12:02