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Titolo:
SEQUENCE AND STRUCTURE SIMILARITIES OF CATHEPSIN-B FROM THE PARASITE SCHISTOSOMA-MANSONI AND HUMAN LIVER
Autore:
KLINKERT MQ; CIOLI D; SHAW E; TURK V; BODE W; BUTLER R;
Indirizzi:
CNR,INST CELL BIOL ROME ITALY FRIEDRICH MIESCHER INST CH-4002 BASEL SWITZERLAND JOZEF STEFAN INST LJUBLJANA SLOVENIA MAX PLANCK INST BIOCHEM W-8033 MARTINSRIED GERMANY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 351, anno: 1994,
pagine: 397 - 400
SICI:
0014-5793(1994)351:3<397:SASSOC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEINASES; INVITRO;
Keywords:
CATHEPSIN B; SCHISTOSOMA MANSONI; HUMAN LIVER; STRUCTURAL COMPARISON; INHIBITOR MODELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M.Q. Klinkert et al., "SEQUENCE AND STRUCTURE SIMILARITIES OF CATHEPSIN-B FROM THE PARASITE SCHISTOSOMA-MANSONI AND HUMAN LIVER", FEBS letters, 351(3), 1994, pp. 397-400

Abstract

A three-dimensional structure of Schistosoma mansoni cathepsin B was modelled using the coordinates of the crystal Structure of the human liver enzyme. Both enzymes appear to share remarkable structural similarity. However, an examination of the models complexed with two synthetic inhibitors revealed differences in inhibitor binding, as confirmed by differences in the 50% inhibitory concentration of the same inhibitor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:11:56