Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ATP-SENSITIVE K-MUSCLE CELLS FIRST OPEN AND SUBSEQUENTLY CLOSE AT MAINTAINED ANOXIA( CHANNELS IN HEART)
Autore:
THIERFELDER S; DOEPNER B; GEBHARDT C; HIRCHE H; BENNDORF K;
Indirizzi:
UNIV COLOGNE,ZENTRUM PHYSIOL & PATHOPHYSIOL,ROBERT KOCH STR 39 D-50931 COLOGNE GERMANY UNIV COLOGNE,ZENTRUM PHYSIOL & PATHOPHYSIOL D-50931 COLOGNE GERMANY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 351, anno: 1994,
pagine: 365 - 369
SICI:
0014-5793(1994)351:3<365:AKCFOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG CARDIAC MYOCYTES; GUINEA-PIG; ADENOSINE-TRIPHOSPHATE; CONTRACTILE FAILURE; EXTRACELLULAR K+; GLYCOLYSIS; MEMBRANE; INHIBITION; ISCHEMIA; RELEASE;
Keywords:
PATCH CLAMP; HEART CELL; K-ATP CHANNEL; ANOXIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S. Thierfelder et al., "ATP-SENSITIVE K-MUSCLE CELLS FIRST OPEN AND SUBSEQUENTLY CLOSE AT MAINTAINED ANOXIA( CHANNELS IN HEART)", FEBS letters, 351(3), 1994, pp. 365-369

Abstract

In ventricular myocardial cells of the guinea pig and the mouse, anoxia caused after a mean latency of 439 +/- 141 s and 129 +/- 23 s (mean+/- S.E.M.), respectively, a large current through K-ATP-channels. This current disappeared within several seconds when reoxygenating the cells but decayed also completely at maintained anoxia. The kinetics ofthe latter process, however, were much slower and obeyed an approximately monoexponential time course with time constants in the range of 30 s. The results suggest that in the ischaemic myocardium K-ATP-channels contribute only to the initial phase of extracellular K+ accumulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:42:59