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Titolo:
MECHANISM OF GENE ACTIVATION BY THE ESCHERICHIA-COLI POSITIVE REGULATOR, OMPR - A MUTANT DEFECTIVE IN TRANSCRIPTIONAL ACTIVATION
Autore:
AIBA H; KATO N; TSUZUKI M; MIZUNO T;
Indirizzi:
NAGOYA UNIV,SCH AGR,MOLEC MICROBIOL LAB,CHIKUSA KU NAGOYA 464 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 351, anno: 1994,
pagine: 303 - 307
SICI:
0014-5793(1994)351:3<303:MOGABT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING ABILITY; SIGNAL-TRANSDUCTION; RNA-POLYMERASE; ALPHA-SUBUNIT; RECEPTOR PROTEIN; PHOSPHORYLATION; MUTATIONS; OSMOREGULATION; ENVZ; SITE;
Keywords:
POSITIVE REGULATOR OF ESCHERICHIA-COLI; TRANSCRIPTIONAL ACTIVATION; MUTATION ANALYSIS; OSMOTIC REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Aiba et al., "MECHANISM OF GENE ACTIVATION BY THE ESCHERICHIA-COLI POSITIVE REGULATOR, OMPR - A MUTANT DEFECTIVE IN TRANSCRIPTIONAL ACTIVATION", FEBS letters, 351(3), 1994, pp. 303-307

Abstract

The OmpR protein is an activator specific for the E. coli ompC and ompF genes. This protein functions in a phosphorylation-dependent mannerthrough a presumed interaction with RNA polymerase. In this study we isolated OmpR mutants which were suggested to be defective for transcriptional activation, but not for DNA binding. Two such mutants, that we isolated, have a single amino acid alteration at positions 131 [P131S], and 179 [P179L], respectively, of OmpR, comprising 239 amino acids. These altered amino acids in OmpR may be implicated, directly or indirectly, in the presumed RNA polymerase/OmpR interaction that is important for transcriptional activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 17:59:42