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Titolo:
MUTAGENICITY OF TRANS,TRANS-MUCONALDEHYDE AND ITS METABOLITES IN V79 CELLS
Autore:
CHANG RL; WONG CQ; KLINE SA; CONNEY AH; GOLDSTEIN BD; WITZ G;
Indirizzi:
ENVIRONM & OCCUPAT HLTH SCI INST,681 FRELINGHUYSEN RD PISCATAWAY NJ 08855 RUTGERS STATE UNIV,COLL PHARM,DEPT CHEM BIOL & PHARMACOGNOSY,CANC RESLAB PISCATAWAY NJ 08855 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT ENVIRONM & COMMUNITY MED PISCATAWAY NJ 08854
Titolo Testata:
Environmental and molecular mutagenesis
fascicolo: 2, volume: 24, anno: 1994,
pagine: 112 - 115
SICI:
0893-6692(1994)24:2<112:MOTAIM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN-CELLS; BENZENE; IDENTIFICATION; MUCONALDEHYDE; BACTERIAL; PATHWAYS; PRODUCTS; TOXICITY; ACID;
Keywords:
RING-OPENED BENZENE METABOLITES; HGPRT MUTATIONS; MUCONALDEHYDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Chang et al., "MUTAGENICITY OF TRANS,TRANS-MUCONALDEHYDE AND ITS METABOLITES IN V79 CELLS", Environmental and molecular mutagenesis, 24(2), 1994, pp. 112-115

Abstract

trans,trans-Muconaldehyde (MUC), a six-carbon-diene-dialdehyde, is a microsomal, hematotoxic ring-opened metabolite of benzene. MUC is metabolized to a variety of compounds which are formed by oxidation and/orreduction of the aldehyde group(s). In the present studies, MUC and its metabolites were examined for mutagenic activity at the hypoxanthine guanine phosphoribosyltransferase (HGPRT) locus in Chinese hamster V79 cells. Mutagenicity was scored by counting 8-azaguanine-resistant colonies. Of the 6 compounds tested, MUC and its aldehydic metabolites 6-hydroxy-trans,trans-2,4-hexadienal and 6-oxo-trans,trans-hexadienoicacid were mutagenic in that order of potency. The other MUC metabolites tested (1,6-dihydroxy-trans, trans-2, 4-hexadiene, trans, trans-muconic acid, and 6-hydroxy-trans, trans-2,4-hexadienoic acid) had littleor no activity in this system. The order of mutagenic activity of MUCand its aldehydic metabolites correlates with their reactivity towards glutathione, suggesting that alkylating potential is important in the genotoxicity of these compounds. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 12:48:16