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Titolo:
MR-IMAGING DETECTION OF CEREBRAL METASTASES WITH A SINGLE INJECTION OF HIGH-DOSE GADOTERIDOL
Autore:
RUNGE VM; WELLS JW; NELSON KL; LINVILLE PM;
Indirizzi:
UNIV KENTUCKY,CTR MAGNET RESONANCE IMAGING & SPECTR,RM 109,MRISC BLDGLEXINGTON KY 40536 NUCL MED INC OMAHA NE 00000
Titolo Testata:
Journal of magnetic resonance imaging
fascicolo: 5, volume: 4, anno: 1994,
pagine: 669 - 673
SICI:
1053-1807(1994)4:5<669:MDOCMW>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Keywords:
BRAIN NEOPLASMS, MR; BRAIN NEOPLASMS, SECONDARY; CONTRAST ENHANCEMENT; GADOLINIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
V.M. Runge et al., "MR-IMAGING DETECTION OF CEREBRAL METASTASES WITH A SINGLE INJECTION OF HIGH-DOSE GADOTERIDOL", Journal of magnetic resonance imaging, 4(5), 1994, pp. 669-673

Abstract

The utility of a single high-dose (0.3 mmol/kg) injection of gadoteridol, a gadolinium chelate, in the detection of brain metastases on magnetic resonance images was studied. Patients (n = 29) with a high suspicion for brain metastases at clinical examination and by history wereimaged on two occasions-separated by more than 24 hours and less than7 days-with a 0.1 mmol/kg contrast agent dose used for the first study and a 0.3 mmol/kg dose for the second. In patients (n = 15) with confirmed brain metastases by clinical, radiologic, and/or histologic criteria, 40 lesions were detected at the 0.3 mmol/kg dose by a single reader blinded to contrast agent dose, compared with 33 lesions at 0.1 mmol/kg, a 21% increase. Three of 15 patients (20%) demonstrated an increase in the number of lesions detected at the higher dose. Region-of-interest analysis of signal intensity measurements showed that lesion contrast (relative to normal brain) improved from 54% at 0.1 mmol/kg to 92% at 0.3 mmol/kg. A 0.3 mmol/kg dose of gadoteridol, administered in a single injection, permits identification of brain metastases not detected at 0.1 mmol/kg. Such information can influence the choice of therapy.

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Documento generato il 05/12/20 alle ore 01:14:38