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Titolo:
LEUKOCYTE RECRUITMENT BY MONOCYTE CHEMOTACTIC PROTEINS (MCPS) SECRETED BY HUMAN PHAGOCYTES
Autore:
WUYTS A; PROOST P; PUT W; LENAERTS JP; PAEMEN L; VANDAMME J;
Indirizzi:
CATHOLIC UNIV LEUVEN,REGA INST,MOLEC IMMUNOL LAB,MINDEBROEDERSSTR 10 B-3000 LOUVAIN BELGIUM CATHOLIC UNIV LEUVEN,REGA INST,MOLEC IMMUNOL LAB B-3000 LOUVAIN BELGIUM
Titolo Testata:
Journal of immunological methods
fascicolo: 1-2, volume: 174, anno: 1994,
pagine: 237 - 247
SICI:
0022-1759(1994)174:1-2<237:LRBMCP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATING FACTOR MCAF; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; BLOOD MONONUCLEAR LEUKOCYTES; TUMOR-NECROSIS-FACTOR; AMINO-ACID ANALYSIS; CHEMOATTRACTANT PROTEIN-1; EPITHELIAL-CELLS; GENE-EXPRESSION; MOLECULAR-CLONING; ENDOTHELIAL-CELLS;
Keywords:
CHEMOTAXIS; CHEMOKINE; MONOCYTE CHEMOTACTIC PROTEIN; INTERLEUKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
A. Wuyts et al., "LEUKOCYTE RECRUITMENT BY MONOCYTE CHEMOTACTIC PROTEINS (MCPS) SECRETED BY HUMAN PHAGOCYTES", Journal of immunological methods, 174(1-2), 1994, pp. 237-247

Abstract

Phagocyte recruitment is an important immunological phenomenon in inflammation arid cancer. A large family of selective chemotactic cytokines, designated chemokines, has recently emerged. Interleukin-8 (IL-8) is the prototype of such neutrophil activating factors, whereas MCP-1 is a well studied monocyte chemotactic protein. In vitro chemotactic assays were used to isolate and identify natural chemokines from mononuclear phagocytes and tumor cells. Additional new chemotactic proteins (MCP-2, MCP-3) attracting monocytes were also discovered by these methods. All chemokines are structurally related and show affinity for heparin. MCP-1, -2 and -3 have a comparable specific activity in monocytechemotaxis assays. Specific and sensitive radioimmunoassays for MCP-1and IL-8 were developed to study the regulation of their secretion byleukocytes. Monocytes or monocyte tumor cells produce MCP-1 and/or IL-8 in response to cytokines, virus, double stranded RNA, bacterial endotoxin, mitogen or phorbol ester. Granulocytes were found to secrete only minor amounts of MCP-1 and IL-8.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:15:19