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Titolo:
IODINE-123-IBZM-SPECT - STUDIES IN 15 PATIENTS WITH PITUITARY-TUMORS
Autore:
PIRKER W; BRUCKE T; RIEDL M; CLODI M; LUGER A; ASENBAUM S; PODREKA I; DEECKE L;
Indirizzi:
UNIV VIENNA,NEUROL CLIN,WAEHRINGER GUERTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,INTERNAL MED CLIN 3 VIENNA AUSTRIA
Titolo Testata:
Journal of neural transmission
fascicolo: 3, volume: 97, anno: 1994,
pagine: 235 - 244
SICI:
0300-9564(1994)97:3<235:I-SI1P>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-125 EPIDEPRIDE; HUMAN BRAIN; DOPAMINE; RECEPTORS; BROMOCRIPTINE; PROLACTINOMAS; ADENOMAS; SPECT;
Keywords:
SPECT; IODOBENZAMIDE; PITUITARY ADENOMAS; DOPAMINE; D-2 RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
W. Pirker et al., "IODINE-123-IBZM-SPECT - STUDIES IN 15 PATIENTS WITH PITUITARY-TUMORS", Journal of neural transmission, 97(3), 1994, pp. 235-244

Abstract

Single photon emission computerized tomography (SPECT) using the Iodine 123 labeled dopamine D-2 receptor antagonist S(-)Iodobenzamide [S (-)IBZM] was performed in 15 patients with pituitary tumors. Among themthere were five prolactinoma patients with macroadenoma and two acromegalic patients with macroadenoma. Specific binding in the area of theadenoma was only observed in one subject, a macroprolactinoma patient, who was responsive to dopaminergic treatment. None of the other patients, among them one macroprolactinoma patient responsive to dopaminergic treatment showed specific binding in the area of the tumor. IBZM-binding in the striatum was found to be significantly lower in the group of pituitary tumor patients as compared to controls. The results show that D2 receptors in pituitary adenomas can be visualized using SPECT. However, the sensitivity of IBZM-SPECT appears to be too poor to visualize PRL- and GH- secreting macroadenomas in general.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/10/19 alle ore 23:19:32