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Titolo:
CENTRALLY-ADMINISTERED GLYCINE ANTAGONISTS INCREASE LOCOMOTION IN MONOAMINE-DEPLETED MICE
Autore:
SLUSHER BS; RISSOLO KC; JACKSON PF; PULLAN LM;
Indirizzi:
ZENECA PHARMACEUT GRP,DEPT PHARMACOL,CNS SECT,1800 CONCORD PIKE WILMINGTON DE 19897
Titolo Testata:
Journal of neural transmission
fascicolo: 3, volume: 97, anno: 1994,
pagine: 175 - 185
SICI:
0300-9564(1994)97:3<175:CGAILI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA-RECEPTOR; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; MK-801; ASPARTATE; DOPAMINE; RATS; NBQX; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM;
Keywords:
RESERPINE; ALPHA-METHYL-PARA-TYROSINE; PARKINSONS DISEASE; GLUTAMATE; DOPAMINE; NMDA RECEPTORS; GLYCINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Slusher et al., "CENTRALLY-ADMINISTERED GLYCINE ANTAGONISTS INCREASE LOCOMOTION IN MONOAMINE-DEPLETED MICE", Journal of neural transmission, 97(3), 1994, pp. 175-185

Abstract

It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, andtwo of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of akinesia when administered intrastriatally to monoamine depleted mice. Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation. In addition, all glycine antagonists tested did not cause significant locomotor stimulation when intrastriatally administered to normal mice. These data suggest that glycine antagonists may offer therapeutic utility in the treatment of idiopathic Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:51:10