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Titolo:
CEREBRAL VASOCONSTRICTIVE RESPONSE PRODUCED BY CHEMICAL-STIMULATION OF THE CAUDAL VENTROLATERAL MEDULLARY DEPRESSOR AREA IS MEDIATED VIA THE ROSTRAL VENTROLATERAL MEDULLARY PRESSER AREA AND THE CERVICAL SYMPATHETIC-NERVES
Autore:
MAEDA M; HAYASHIDA Y; NAKAI M; KRIEGER AJ; SAPRU HN;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,DEPT SYST PHYSIOL,YAHATANISHI KU,1-1 ISEIGAOKA KITAKYUSHU 807 FUKUOKA JAPAN NATL CARDIOVASC CTR SUITA OSAKA 565 JAPAN UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,NEUROL SURG SECT NEWARKNJ 07103
Titolo Testata:
Journal of the autonomic nervous system
, volume: 49, anno: 1994, supplemento:, S
pagine: 190000025 - 190000029
SICI:
0165-1838(1994)49:<190000025:CVRPBC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS TRACTUS-SOLITARII; CORD BLOOD-FLOW; ANESTHETIZED RATS; BRAIN; NEURONS; MECHANISMS; GLUTAMATE;
Keywords:
CEREBROVASCULAR CIRCULATION; CARDIOVASCULAR CENTER; VENTROLATERAL MEDULLA; VASOMOTOR SYSTEM; CERVICAL SYMPATHETIC NERVE; CHEMICAL STIMULATION; CHEMICAL INHIBITION; MICROSPHERE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M. Maeda et al., "CEREBRAL VASOCONSTRICTIVE RESPONSE PRODUCED BY CHEMICAL-STIMULATION OF THE CAUDAL VENTROLATERAL MEDULLARY DEPRESSOR AREA IS MEDIATED VIA THE ROSTRAL VENTROLATERAL MEDULLARY PRESSER AREA AND THE CERVICAL SYMPATHETIC-NERVES", Journal of the autonomic nervous system, 49, 1994, pp. 190000025-190000029

Abstract

It was investigated that the cerebral blood flow (CBF) decrease response elicited by chemical stimulation of the caudal ventrolateral medullary depressor area (VLDA) is mediated via the rostral ventrolateral medullary presser area (VLPA) and the cervical sympathetic nerve. The CBF was determined by radiolabeled microsphere technique in urethane (1.1-1.5 g kg(-1), i.p.) anesthetized Wistar rats. (i) Microinjection ofL-glutamate (1.7 nmol) into the VLDA produced a significant (P < 0.01) decrease in CBF from 64 +/- 9 (mean +/- SEM) to 48 +/- 9 ml min(-1) (100 g)(-1) and a significant (P < 0.01) increase in cerebrovascular resistance (CVR) from 1.7 +/- 0.2 to 2.4 +/- 0.4 mmHg per [ml min(-1) (100 g)(-1)] in the cerebral cortex ipsilateral to the stimulated VLDA side (n = 9). (ii) After cervical sympathectomy, L-glutamate was unilaterally microinjected into the VLDA. The CBF and CVR did not change significantly (n = 10). (iii) After depression of the VLPA neurons with muscimol (GABA agonist), L-glutamate was unilaterally microinjected into the VLDA. The CBF and CVR did not change significantly (n = 14). These results suggest that the pathway from the VLDA to control cerebralvessels may be mediated via the VLPA and the cervical sympathetic nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:03:11