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Titolo:
NICOTINIC CHOLINERGIC RECEPTORS ASSOCIATED WITH MAMMALIAN CEREBRAL VESSELS
Autore:
KALARIA RN; HOMAYOUN P; WHITEHOUSE PJ;
Indirizzi:
CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROL BRB5,10900 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROSCI CLEVELAND OH 44106 UNIV CLEVELAND HOSP,ALZHEIMER CTR CLEVELAND OH 44106
Titolo Testata:
Journal of the autonomic nervous system
, volume: 49, anno: 1994, supplemento:, S
pagine: 190000003 - 190000007
SICI:
0165-1838(1994)49:<190000003:NCRAWM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACEREBRAL BLOOD-VESSELS; ALZHEIMER-DISEASE; ACETYLTRANSFERASE ACTIVITY; CORTEX CAPILLARIES; BASAL FOREBRAIN; HUMAN-BRAIN; RAT; ACETYLCHOLINE; FLOW; MICROVESSELS;
Keywords:
ACETYLCHOLINE; CARBACHOL; CEREBRAL VESSEL; CHOLINERGIC RECEPTOR; LIGAND BINDING; NICOTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Kalaria et al., "NICOTINIC CHOLINERGIC RECEPTORS ASSOCIATED WITH MAMMALIAN CEREBRAL VESSELS", Journal of the autonomic nervous system, 49, 1994, pp. 190000003-190000007

Abstract

Current evidence suggests that the cerebral vasculature may be modulated by cholinergic nerves. We used ligand binding methods to examine the presence of nicotinic cholinergic receptors in brain vasculature. We found carbachol-displaceable [H-3]acetylcholine (ACh) and [H-3]nicotine (NIC) binding sites in preparations of intraparenchymal cerebral microvessels (CMV) and larger pial vessels from human and pig brains. Specific binding sites for [H-3]ACh and [H-3]NIC in cerebral microvessels were saturable and comparable in density to those in cerebral cortex. The K(d)s for the two ligands ranged 3-18 nM whereas the B(max)s were 25-45 fmol/mg protein. In contrast, the binding of [H-3]pirenzipineor [H-3]quinuclidinyl benzilate, index for muscarinic receptors, was low (9-15% of cortex) in microvessels compared to the cerebral cortex. Our observations suggest the association of cholinergic nicotinic receptors with cerebral microvessels, which may be involved in the modulation of the cerebral circulation by cholinergic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 00:43:30