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Titolo:
SPECTRUM OF EEG ABNORMALITIES DURING CLOZAPINE TREATMENT
Autore:
MALOW BA; REESE KB; SATO S; BOGARD PJ; MALHOTRA AK; SU TP; PICKAR D;
Indirizzi:
NINCDS,EEG SECT,BLDG 10,ROOM 5C-101 BETHESDA MD 20892 NINCDS,EEG SECT BETHESDA MD 20892 NIMH,EXPTL THERAPEUT BRANCH BETHESDA MD 00000 MAINE MED CTR,DEPT PSYCHIAT PORTLAND ME 00000
Titolo Testata:
Electroencephalography and clinical neurophysiology
fascicolo: 3, volume: 91, anno: 1994,
pagine: 205 - 211
SICI:
0013-4694(1994)91:3<205:SOEADC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURES; SCHIZOPHRENIA; THERAPY;
Keywords:
CLOZAPINE; EEG; MYOCLONUS; EPILEPTIFORM ABNORMALITIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Malow et al., "SPECTRUM OF EEG ABNORMALITIES DURING CLOZAPINE TREATMENT", Electroencephalography and clinical neurophysiology, 91(3), 1994, pp. 205-211

Abstract

Clozapine is a novel antipsychotic agent effective in treating refractory schizophrenia. Clozapine produces fewer extrapyramidal effects than other neuroleptics, although agranulocytosis and seizures are significant adverse effects. To characterize the spectrum of clozapine-related electroencephalographic abnormalities, we identified 10 patients who had electroencephalograms (EEGs) performed before and during clozapine treatment. These 10 patients represented a subset of individuals participating in an investigational trial. During clozapine treatment, five developed myoclonus and one experienced a generalized tonic-clonic seizure. Records were retrospectively reviewed by an electroencephalographer blinded to the patient's history and medications. All patients had normal EEGs before clozapine treatment. While receiving clozapine (250-900 mg daily), all patients developed background slowing in thetheta and often delta ranges. Additionally, 7 patients exhibited bilateral spike, polyspike and slow wave discharges, one with a photoparoxysmal response. Follow-up EEGs performed in 4 of these 7 patients after a decrease in clozapine dosage and/or addition in valproic acid showed diminished epileptiform activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:26:18