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Titolo:
THE PREVALENCE AND RESPONSE TO THERAPY OF STRONGYLOIDES-STERCORALIS IN PATIENTS WITH ASTHMA FROM ENDEMIC AREAS

Autore:

WEHNER JH; KIRSCH CM; KAGAWA FT; JENSEN WA; CAMPAGNA AC; WILSON M;

Indirizzi:: SANTA CLARA VALLEY MED CTR,DIV RESP & CRIT CARE MED,751 S BASCOM AVE SAN JOSE CA 95128 SANTA CLARA VALLEY MED CTR,DIV RESP & CRIT CARE MED SAN JOSE CA 95128 STANFORD UNIV,SCH MED,DIV PULM & CRIT CARE MED STANFORD CA 00000 CTR DIS CONTROL & PREVENT,DIV PARASIT DIS ATLANTA GA 00000
Titolo Testata:: Chest
fascicolo: 3, volume: 106, anno: 1994,
pagine: 762 - 766
SICI:: 0012-3692(1994)106:3<762:TPARTT>2.0.ZU;2-5
Fonte:: ISI
Lingua:: ENG
Soggetto:: LINKED IMMUNOSORBENT-ASSAY; INTESTINAL PARASITES; INFECTION; PRISONERS; FEATURES; ANTIGENS; VALUES; WAR;
Keywords:: ASTHMA; EOSINOPHIL; STRONGYLOIDES STERCORALIS;
Tipo documento:: Article
Natura:: Periodico
Settore Disciplinare:: Science Citation Index Expanded
Citazioni:: 36
Recensione:
Indirizzi per estratti:



Citazione:: J.H. Wehner et al., "THE PREVALENCE AND RESPONSE TO THERAPY OF STRONGYLOIDES-STERCORALIS IN PATIENTS WITH ASTHMA FROM ENDEMIC AREAS", Chest, 106(3), 1994, pp. 762-766

Abstract

Study objective: To evaluate the prevalence and response to therapy of Strongyloides stercoralis infection in immigrant patients with asthma from areas endemic for Strongyloides. Design and interventions: In all patients, we performed a complete history and physical examination,complete blood cell counts (CBC), S stercoralis serologic tests, spirometry, and evaluated three stool samples for ova and parasites. Patients treated for S stercoralis infection had follow-up CBC, spirometry,serologic tests, and at least three additional stool examinations to confirm eradication of the parasite. Setting: Ambulatory and hospitalized patients who were referred to the respiratory medicine clinic of ageneral hospital for the evaluation and treatment of asthma. Patients: Forty-five asthmatic adults, representing 12 endemic countries, ranging in age from 20 to 76 years, were prospectively evaluated. Results:Six of 45 patients were infected with S stercoralis, which yielded a prevalence of 13 percent. The patients. with asthma and S stercoralis infection had higher blood eosinophil counts (p=0.006) and were younger (p=0.006) compared with patients with only asthma. There was no difference in the duration of asthma, spirometry, or steroid use between the two groups. Patients with S stercoralis and asthma tended to be more recent immigrants (p=0.05). Five of the six patients with S stercoralis agreed to be treated with thiabendazole but only four returned forfollow-up evaluation. All four patients had eradication of S stercoralis infection confirmed by negative stool examinations and a decline in S stercoralis serology (160+/-25 percent vs 13+/-13 percent, p=0.03). All four patients had a decline in total blood eosinophil counts (2,476+/-832 cells per cubic millimeter vs 551+/-138 cells per cubic millimeter, p=0.03) without a clinical improvement in asthma. Conclusions:Our data suggest that patients with asthma from areas endemic for S stercoralis, who have elevated peripheral blood eosinophil counts, should be screened for S stercoralis infection. Successful eradication of S stercoralis, however, may not result in a clinical improvement of asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:29:02