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Titolo:
ACADESINE IMPROVES TOLERANCE TO ISCHEMIC-INJURY IN RAT CARDIAC MYOCYTES
Autore:
GRUVER EJ; TOUPIN D; SMITH TW; MARSH JD;
Indirizzi:
WAYNE STATE UNIV,SCH MED,421 E CANFIELD DETROIT MI 48201 WAYNE STATE UNIV,SCH MED DETROIT MI 48201 BRIGHAM & WOMENS HOSP,DEPT MED,DIV CARDIOVASC BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 00000 HARPER GRACE HOSP,DIV CARDIOL DETROIT MI 00000
Titolo Testata:
Journal of Molecular and Cellular Cardiology
fascicolo: 9, volume: 26, anno: 1994,
pagine: 1187 - 1195
SICI:
0022-2828(1994)26:9<1187:AITTII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR MYOCYTES; CONTRACTILE FAILURE; SIMULATED ISCHEMIA; HEART-CELLS; ADENOSINE; REPERFUSION; CALCIUM; PRECURSORS; MECHANISMS; INHIBITION;
Keywords:
ISCHEMIA; ADENOSINE; MYOCYTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Gruver et al., "ACADESINE IMPROVES TOLERANCE TO ISCHEMIC-INJURY IN RAT CARDIAC MYOCYTES", Journal of Molecular and Cellular Cardiology, 26(9), 1994, pp. 1187-1195

Abstract

The ability of acadesine to modulate injury in a myocyte model of simulated ischemia was studied. When freshly isolated adult rat ventricular myocytes were subjected to 10 min of simulated ischemia and reperfusion, greater that 75% of myocytes developed hypercontracture and the amplitude of contraction of the remaining, potentially viable myocyteswas markedly depressed. When cells were pretreated with 50 mu M acadesine for 5 min and exposed to acadesine during simulated ischemia and during 2-10 min of reperfusion, followed by reperfusion with control buffer, up to 90% of myocytes maintained normal morphology and could bestimulated to contract. Acadesine alone had no significant effect on amplitude of contraction of the myocytes. Acadesine is known to alter adenosine metabolism and to increase coronary sinus [adenosine] in theischemic heart. When cells were treated with the non-selective adenosine receptor antagonist 8-sulfonylphenyltheophylline, the protective effect of acadesine was abolished. Thus, in this adult rat cardiac myocyte model of simulated ischemia, acadesine protects partially against ischemia/reperfusion injury. The protective effect of acadesine is mediated, at least in part, by an adenosine receptor-dependent mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 11:03:42