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Titolo:
SYSTEMIC AND LOCAL THROMBOLYTIC THERAPY W ITH RT-PA (ACTILYSE(R)) IN CHILDREN WITH CONGENITAL HEART-DISEASE
Autore:
RIES M; SINGER H; HOFBECK M; KLINGE J; WILD F; VOGEL P;
Indirizzi:
UNIV ERLANGEN NURNBERG,KINDER & JUGENDL KLIN & POLIKLIN,LOSCHGESTR 15D-91054 ERLANGEN GERMANY
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 3, volume: 142, anno: 1994,
pagine: 205 - 208
SICI:
0026-9298(1994)142:3<205:SALTTW>2.0.ZU;2-I
Fonte:
ISI
Lingua:
GER
Keywords:
THROMBOLYTIC THERAPY; RT-PA; CHILDREN; CONGENITAL HEART DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M. Ries et al., "SYSTEMIC AND LOCAL THROMBOLYTIC THERAPY W ITH RT-PA (ACTILYSE(R)) IN CHILDREN WITH CONGENITAL HEART-DISEASE", Monatsschrift fur Kinderheilkunde, 142(3), 1994, pp. 205-208

Abstract

Background: We report our experience with the local and systemic application of recombinant tissue plasminogen activator (rt-PA) in 6 children aged 11 months-11 7/12 years suffering from various thromboembolicstates including left atrial thrombus with prosthesis dysfunction, thrombosed femoral artery after cardiac catherization and thrombosed modified Blalock-Taussig-shunts. Method: Systemic thrombolytic therapy was started with 0.5 mg/kg rt-PA as a slow bolus injection over 30 min followed by an infusion of 0.5 mg/kg/day for 2 or 3 days. One child wassuccessfully treated with a dosage of 0.3 mg/kg/day for 3 days without bolus injection. For local thrombolytic therapy into the aortopulmonary shunts rt-PA was applicated in 4 single doses of 0.2 mg/kg in 1 patient and 0.1 mg/kg in the other. Results: Complete clot dissolution and clinical improvement occurred in 5 children. A bleeding complication was noted in one of the 6 patients and controlled by infusion of erythrocyte concentrate. Conclusion: We conclude that recombinant tissue plasminogen activator is effective in inducing clot lysis and a good alternative to therapy with urokinase, streptokinase or surgical treatment.

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Documento generato il 26/09/20 alle ore 06:49:34