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Titolo:
NO IMPROVEMENT IN SURVIVAL FROM MELANOMA DIAGNOSED FROM 1973 TO 1984
Autore:
BERWICK M; DUBIN N; LUO ST; FLANNERY J;
Indirizzi:
CANC PREVENT RES INST,11 E 22ND ST NEW YORK NY 10010 NYU,MED CTR,DEPT ENVIRONM MED NEW YORK NY 10016 NYU,MED CTR,KAPLAN COMPREHENS CANC CTR NEW YORK NY 10016 CONNECTICUT TUMOR REGISTRY HARTFORD CT 06106
Titolo Testata:
International journal of epidemiology
fascicolo: 4, volume: 23, anno: 1994,
pagine: 673 - 681
SICI:
0300-5771(1994)23:4<673:NIISFM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS MALIGNANT-MELANOMA; PROGNOSTIC FACTORS; UNITED-STATES; BREAST-CANCER; INCREASING INCIDENCE; REGRESSION-ANALYSIS; FEMALE SUPERIORITY; SKIN-MELANOMA; TRENDS; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Berwick et al., "NO IMPROVEMENT IN SURVIVAL FROM MELANOMA DIAGNOSED FROM 1973 TO 1984", International journal of epidemiology, 23(4), 1994, pp. 673-681

Abstract

Background. While the incidence and mortality of melanoma has increased dramatically during the last few decades, survival rates, based on the case-fatality ratio, have apparently improved. Efforts at early detection have probably been effective in the discovery of lesions at a curable stage. However, the effects of lead-time bias need to be accounted for in order to understand the contribution of early detection tothe increased incidence. This can best be done by appropriately controlling for depth of the tumour or a surrogate of depth, at diagnosis. Methods. A survival analysis was conducted for 3197 Connecticut residents newly diagnosed with invasive melanoma between 1973 and 1984. Fiveprognostic variables were evaluated: sex, age at diagnosis, anatomical site, histological type, and year of diagnosis. Results. As expected, women and the young had better survival than men and the elderly. Melanomas located on the trunk had poorer prognosis than those on other sites. The survival experience by histological type was significantly different; lentigo maligna melanoma and superficial spreading melanomahad the best survival and nodular melanomas the poorest, while 'other' and unclassifiable melanomas had intermediate survival. When survival by period of diagnosis was controlled by other variables, which included surrogates for disease stage, there was no improvement in survival over time. Conclusion. These data do not imply that early diagnosis and treatment are ineffective; rather, that within stages of disease, survival improvements did not occur during the period 1973-1984.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:13:02