Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIAZEPAM WITHDRAWAL INCREASES [H-3] 5-HT RELEASE FROM RAT AMYGDALOID SLICES
Autore:
FERNANDES C; ANDREWS N; FILE SE;
Indirizzi:
UNITED MED & DENT SCH,DIV PHARMACOL,PSYCHOPHARMACOL RES UNIT LONDON SE1 9RT ENGLAND UNITED MED & DENT SCH,DIV PHARMACOL,PSYCHOPHARMACOL RES UNIT LONDON SE1 9RT ENGLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 49, anno: 1994,
pagine: 359 - 362
SICI:
0091-3057(1994)49:2<359:DWI[5R>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT RELEASE; BENZODIAZEPINE;
Keywords:
AMYGDALA; HIPPOCAMPUS; 5-HT; GABA; ANXIETY; BENZODIAZEPINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
C. Fernandes et al., "DIAZEPAM WITHDRAWAL INCREASES [H-3] 5-HT RELEASE FROM RAT AMYGDALOID SLICES", Pharmacology, biochemistry and behavior, 49(2), 1994, pp. 359-362

Abstract

The release of [H-3]-5-HT and [C-14]-GABA from hippocampal and amygdaloid slices was studied in a group of rats in which an anxiogenic response had been found on withdrawal of chronic diazepam treatment (2 mg/kg/day for 21 days). Basal release and uptake of [H-3]-5-HT and [C-14]-GABA and K+-evoked release of [C-14]-GABA were not significantly changed in either brain region following diazepam withdrawal. However, there was a significant increase in K+-evoked [H-3]-5-HT release from theamygdala, but not from the hippocampal, slices. These results demonstrate that increased 5-HT release from the hippocampus is not necessaryto mediate the anxiogenic withdrawal response, and that raised 5-HT release in the amygdala may be sufficient to mediate this response. Theresults are discussed with respect to conditions, such as noise during diazepam treatment, that might produce regionally specific changes in 5-HT tone and hence modify the pattern of changes found during diazepam withdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:52:53