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Titolo:
THE DIRECT INFLUENCE OF THE EMBRYO ON UTERINE PGF(2-ALPHA) AND PGE(2)PRODUCTION IN SHEEP
Autore:
PAYNE JH; LAMMING GE;
Indirizzi:
UNIV NOTTINGHAM,AFRC,HORMONES & FARM ANIM REPROD RES GRP,SUTTON BONINGTON CAMPUS NOTTINGHAM LE12 5RD LEICS ENGLAND
Titolo Testata:
Journal of Reproduction and Fertility
fascicolo: 3, volume: 101, anno: 1994,
pagine: 737 - 741
SICI:
0022-4251(1994)101:3<737:TDIOTE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROPHOBLAST PROTEIN-1; ENDOMETRIUM INVITRO; OXYTOCIN-RECEPTOR; EARLY-PREGNANCY; ESTROUS-CYCLE; EWE; ESTRADIOL; SECRETION; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Payne e G.E. Lamming, "THE DIRECT INFLUENCE OF THE EMBRYO ON UTERINE PGF(2-ALPHA) AND PGE(2)PRODUCTION IN SHEEP", Journal of Reproduction and Fertility, 101(3), 1994, pp. 737-741

Abstract

In unilateral pregnant ewes, obtained by surgically transecting one uterine horn to isolate it from the rest of the pregnant uterus, the isolated hem develops endometrial oxytocin receptors by day 16 despite being in a hormonal environment equivalent of that of a pregnant ewe. This study examines uterine prostaglandin production in these animals. On day 16 of pregnancy, ewes were anaesthetized and a uterine vein draining each horn and the jugular vein cannulated. Venous blood samples were taken at 10 min intervals for 1 h before and 1 h after an i.v. injection of oxytocin (1 mu g). Uterine vein samples were assayed for PGF(2 alpha) and PGE(2) and jugular blood samples assayed for 13,14-dihydro,15-keto-PGF(2 alpha). All ewes showed high plasma concentrations of 13,14-dihydro,15-keto-PGF(2 alpha) after the oxytocin injection. PGF(2 alpha) increased in the uterine vein draining the nonpregnant transected horn of a unilaterally pregnant ewe following oxytocin treatment, whereas there was no increase in concentration in plasma draining the pregnant hem. Basal plasma PGF(2 alpha) concentrations from the uterine vein draining the pregnant horn were significantly higher than concentrations obtained from the uterine vein of the transected horn while PGE(2) concentrations did not vary between the two hems. After oxytocin injection, there was a significant increase in plasma PGE(2) concentration in venous blood collected from both sides. These results indicate that (1) oxytocin receptors present in the isolated nonpregnant horn can be stimulated by oxytocin to produce PGF(2 alpha), despite thesteroid environment being that of a pregnant ewe; (2) the presence ofthe conceptus locally inhibits the endometrial PGF(2 alpha) production following the challenge but enhances baseline production; (3) PGE(2)production does not differ between the pregnant and nonpregnant uterine hems of ewes with transected uteri and (4) oxytocin causes a bilateral increase in venous PGE(2) concentrations draining pregnant and nonpregnant uterine horns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:56:03