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Titolo:
CHARACTERIZATION OF A NOVEL BINDING-SITE FOR THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE PROTEIN GP120 ON HUMAN FETAL ASTROCYTES
Autore:
MA MH; GEIGER JD; NATH A;
Indirizzi:
UNIV MANITOBA,DEPT MED MICROBIOL,523-730 WILLIAM AVE WINNIPEG R3E 0W3MB CANADA UNIV MANITOBA,DEPT MED MICROBIOL WINNIPEG R3E 0W3 MB CANADA UNIV MANITOBA,DEPT PHARMACOL & THERAPEUT WINNIPEG R3E 0W3 MB CANADA UNIV MANITOBA,DEPT INTERNAL MED,NEUROL SECT WINNIPEG R3E 0W3 MB CANADA
Titolo Testata:
Journal of virology
fascicolo: 10, volume: 68, anno: 1994,
pagine: 6824 - 6828
SICI:
0022-538X(1994)68:10<6824:COANBF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-DEFICIENCY SYNDROME; HUMAN BRAIN CULTURES; HUMAN GLIAL-CELLS; PROGRESSIVE ENCEPHALOPATHY; GALACTOSYL CERAMIDE; MICROGLIAL CELLS; CD4 RECEPTOR; HIV-1; INFECTION; AIDS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Ma et al., "CHARACTERIZATION OF A NOVEL BINDING-SITE FOR THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE PROTEIN GP120 ON HUMAN FETAL ASTROCYTES", Journal of virology, 68(10), 1994, pp. 6824-6828

Abstract

I-125-labeled recombinant gp120 bound to primary cultures of human fetal astrocytes,vith a single class of 260-kDa binding sites, with a K-d of 26 nM and maximal number of binding sites of 29.9 fmol/4 x 10(4) cells. Neither CD4 nor galactocerebroside was detectable on astrocytes, and I-125-labeled recombinant gp120 binding to astrocytes was not blocked by antibodies against galactocerebroside or the gp120 binding domain of CD4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:20:07