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Titolo:
TIMI-GRADE-3 FLOW AND REOCCLUSION AFTER INTRAVENOUS THROMBOLYTIC THERAPY - A POOLED ANALYSIS
Autore:
BARBAGELATA NA; GRANGER CB; OQUELI E; SUAREZ LD; BORRUEL M; TOPOL EJ; CALIFF RM;
Indirizzi:
SOLIS 453 RA-1078 BUENOS AIRES DF ARGENTINA FDN FAVALORO BUENOS AIRES DF ARGENTINA DUKE UNIV,MED CTR,DEPT MED,DIV CARDIOL DURHAM NC 27710 CLEVELAND CLIN FDN CLEVELAND OH 44195
Titolo Testata:
The American heart journal
fascicolo: 3, volume: 133, anno: 1997,
pagine: 273 - 282
SICI:
0002-8703(1997)133:3<273:TFARAI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; TISSUE PLASMINOGEN-ACTIVATOR; LEFT-VENTRICULAR FUNCTION; 12-MONTH FOLLOW-UP; RANDOMIZED TRIAL; CORONARY-ARTERY; INTRACORONARY STREPTOKINASE; REPERFUSION THERAPY; RT-PA; PATENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
N.A. Barbagelata et al., "TIMI-GRADE-3 FLOW AND REOCCLUSION AFTER INTRAVENOUS THROMBOLYTIC THERAPY - A POOLED ANALYSIS", The American heart journal, 133(3), 1997, pp. 273-282

Abstract

Early and sustained flow of grade 3 according to thrombolysis in Myocardial Infarction (TIMI) criteria and reocclusion rates are the key measures that define the physiologic efficacy of thrombolytic agents in the treatment of acute myocardial infarction. We performed a systematic overview of angiographic studies after intravenous thrombolysis withaccelerated and standard-dose tissue-plasminogen activator (TPA), anisoylated plasminogen streptokinase activator complex (APSAC), and streptokinase. There were 5475 angiographic observations from 15 studies for TIMI flow analysis and 3147 angiographic observations from 27 studies for reocclusion. At 60 and 90 minutes, the rates of TIMI grade 3 flow were 57.1% and 63.2%, respectively, with accelerated TPA, 39.5% and50.2% with standard-dose TPA, 40.2% and 50.1% with APSAC, and 31.5% at 90 minutes with streptokinase. Overall reocclusion with standard-dose TPA was 11.8% versus 6.0% for accelerated TPA, 4.2% for streptokinase, and 3.0% for APSAC. Although the incidence of TIMI grade 3 flow increased over time with all thrombolytic regimens, decreased patency wasobserved at 180 minutes with accelerated TPA. Still, accelerated TPA is the most effective agent to establish early (90-minute) TIMI grade 3 flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:16:39