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Titolo:
INVOLVEMENT OF HYPOTHALAMIC SUBSTANCE-P IN THE EFFECT OF PROLACTIN ONDOPAMINE RELEASE
Autore:
ISOVICH E; DIAZ MD; LASAGA M; PISERA D; ZAMBRUNO C; THEAS MS; SEILICOVICH A; DUVILANSKI BH;
Indirizzi:
UNIV BUENOS AIRES,FAC MED,CTR INVEST REPROD,PISO 10 RA-1121 BUENOS AIRES ARGENTINA UNIV BUENOS AIRES,FAC MED,CTR INVEST REPROD RA-1121 BUENOS AIRES ARGENTINA
Titolo Testata:
NeuroReport
fascicolo: 14, volume: 5, anno: 1994,
pagine: 1752 - 1754
SICI:
0959-4965(1994)5:14<1752:IOHSIT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE; MEDIAN-EMINENCE; NERVE-TERMINALS; RAT; PITUITARY; NEURONS;
Keywords:
SUBSTANCE P; DOPAMINE; PROLACTIN; MEDIOBASAL HYPOTHALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E. Isovich et al., "INVOLVEMENT OF HYPOTHALAMIC SUBSTANCE-P IN THE EFFECT OF PROLACTIN ONDOPAMINE RELEASE", NeuroReport, 5(14), 1994, pp. 1752-1754

Abstract

IN order to examine the role of hypothalamic SP in the feedback regulation of prolactin, we studied the effect of prolactin and dopamine onSP concentration and release, and the effect of SP on dopamine release. Hypothalamic fragments from male Wistar rats were incubated in the presence of prolactin, dopamine or SP under basal and K+-stimulated conditions. SP (10(-7) M) stimulated dopamine release, while dopamine (10(-7) M) decreased SP content and release. Prolactin (100 ng ml(-1)) increased SP content and release. An increase in hypothalamic SP content was also found during suckling. In addition, a specific antagonist for SP, Win 62,577, blocked the effect of prolactin on dopamine release. These results show an interaction between SP and dopamine at the hypothalamic level and suggest that SP could mediate the feedback action of prolactin on dopamine release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 21:02:52