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Titolo:
2 RAT HOMOLOGS OF CLATHRIN-ASSOCIATED ADAPTER PROTEINS
Autore:
PEVSNER J; VOLKNANDT W; WONG BR; SCHELLER RH;
Indirizzi:
STANFORD UNIV,MED CTR,HOWARD HUGHES MED INST STANFORD CA 94305 STANFORD UNIV,SCH MED,BECKMAN CTR,HOWARD HUGHES MED INST,DEPT MOLEC &CELLULAR PHYS STANFORD CA 94305
Titolo Testata:
Gene
fascicolo: 2, volume: 146, anno: 1994,
pagine: 279 - 283
SICI:
0378-1119(1994)146:2<279:2RHOCA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COATED VESICLE ADAPTERS; ASSEMBLY POLYPEPTIDES; PLASMA-MEMBRANE; INVITRO BINDING; BETA-ADAPTIN; RECEPTOR; BRAIN; PURIFICATION; COMPLEX; GOLGI;
Keywords:
ASSEMBLY PROTEINS; MEMBRANE TRAFFICKING; RECYCLING; VESICLES; RAY ELECTRIC LOBE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J. Pevsner et al., "2 RAT HOMOLOGS OF CLATHRIN-ASSOCIATED ADAPTER PROTEINS", Gene, 146(2), 1994, pp. 279-283

Abstract

A cDNA clone predicted to encode a 46 757-Da protein was isolated from a library derived from the electric lobe of the ray Discopyge ommata. Two rat homologs, p47A and p47B, were subsequently isolated. These three proteins share approx. 80% amino acid (aa) identity to each otherand have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles. These complexes are involved in receptor-mediated pathways of intracellular transport. Rat p47A mRNA is expressed in all tissues examined, including brain, heart, kidney, liver, lung, muscle and spinal cord. Rat p47B mRNA is detected exclusively in brain and spinal cord, and may participate in nervous system-specific functions such as biogenesis or recycling of synaptic vesicles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:45:16