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Titolo:
MUCOSAL-ASSOCIATED LYMPHOID-TISSUE LYMPHOMA OF THE CONJUNCTIVA
Autore:
HARDMANLEA S; KERRMUIR M; WOTHERSPOON AC; GREEN WT; MORELL A; ISAACSON PG;
Indirizzi:
ST THOMAS HOSP,S WING EYE DEP LONDON SE1 7EH ENGLAND ST THOMAS HOSP,DEPT OPHTHALMOL LONDON ENGLAND UNIV COLL LONDON HOSP,DEPT HISTOPATHOL LONDON ENGLAND
Titolo Testata:
Archives of ophthalmology
fascicolo: 9, volume: 112, anno: 1994,
pagine: 1207 - 1212
SICI:
0003-9950(1994)112:9<1207:MLLOTC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL GASTRIC LYMPHOMA; MALIGNANT-LYMPHOMA; OCULAR ADNEXA; IMMUNOGLOBULIN; TRANSLOCATION; NEOPLASMS; FEATURES; SEQUENCE; SECTIONS; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S. Hardmanlea et al., "MUCOSAL-ASSOCIATED LYMPHOID-TISSUE LYMPHOMA OF THE CONJUNCTIVA", Archives of ophthalmology, 112(9), 1994, pp. 1207-1212

Abstract

The recognition of mucosal-associated lymphoid tissue as a distinct entity has lead to the separate classification of tumors arising in this tissue, ie, the mucosal-associated lymphoid tissue lymphoma, Five patients with mucosal-associated lymphoid tissue lymphoma of the conjunctiva are described herein; four of the five patients had bilateral tumors. Laboratory analysis was done using microscopy, immunophenotyping,gene rearrangement analysis using both Southern blot and polymerase chain reaction techniques, and oncogene (bcl-1, bcl-2, and c-myc) rearrangment studies. Typical mucosal-associated lymphoid tissue lymphoma features were seen in all patients; three of four patients who underwent testing with immunphenotyping had light-chain restriction, four of five patients had a clone detected using Southern blot analysis, and all five patients showed clones on polymerase chain reaction analysis. No patient demonstrated oncogene rearrangement. In all patients, complete physical examinations and laboratory tests did not detect any evidence of systemic spread. After treatment, no evidence of local recurrence or dissemination was found during follow-up ranging from 2 to 3 years.

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Documento generato il 18/09/20 alle ore 16:21:50