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Titolo:
THE BIOLOGICAL PHENOTYPE OF HIV-1 IS USUALLY RETAINED DURING AND AFTER SEXUAL TRANSMISSION
Autore:
FIORE JR; BJORNDAL A; PEIPKE KA; DISTEFANO M; ANGARANO G; PASTORE G; GAINES H; FENYO EM; ALBERT J;
Indirizzi:
KAROLINSKA INST,SWEDISH INST INFECT DIS CONTROL,DEPT CLIN IMMUNOL STOCKHOLM SWEDEN KAROLINSKA INST,SWEDISH INST INFECT DIS CONTROL,DEPT CLIN IMMUNOL STOCKHOLM SWEDEN KAROLINSKA INST,DEPT MICROBIOL & TUMORBIOL STOCKHOLM SWEDEN UNIV BARI,CTR INFECT DIS BARI ITALY KAROLINSKA INST,SWEDISH INST INFECT DIS,DEPT CLIN VIROL STOCKHOLM SWEDEN
Titolo Testata:
Virology
fascicolo: 1, volume: 204, anno: 1994,
pagine: 297 - 303
SICI:
0042-6822(1994)204:1<297:TBPOHI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL; MONONUCLEAR PHAGOCYTES; VIRAL PHENOTYPE; TYPE-1 HIV-1; INFECTION; AIDS; PROGRESSION; MACROPHAGES; VARIANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Fiore et al., "THE BIOLOGICAL PHENOTYPE OF HIV-1 IS USUALLY RETAINED DURING AND AFTER SEXUAL TRANSMISSION", Virology, 204(1), 1994, pp. 297-303

Abstract

The biological phenotype of HIV-1 isolates from 21 subjects with primary HIV-1 infection was determined in primary lymphocytes and monocyte-derived macrophages as well as in three T-cell lines (MT-2, HUT78, and C8166). Seven isolates (33%) replicated on at least one cell line and were classified as rapid/high (n = 6) or intermediate (n = 1), while14 isolates (67%) did not replicate in cell lines and were classifiedas slow/low. All isolates replicated in primary monocyte-derived macrophage cultures. Studies on 10 pairs consisting of index case and seroconverting sexual partner showed that the biological phenotype of HIV-1 was unchanged in nine transmissions, including 5 pairs where a rapid/high virus was transmitted. Most individuals (5 of 6) infected by a rapid/high virus retained this phenotype after seroconversion. These individuals also had significantly lower CD4 lymphocyte counts 1-3 yearsafter infection. Thus, in contrast to what has been suggested by others, we found that HIV-1 variants with rapid/high phenotype were usually not suppressed, neither during sexual transmission nor after seroconversion in the new host. These findings have important implications for the understanding of HIV-1 transmission and pathogenesis as well as for vaccine design. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 14:59:37