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Titolo:
THE ROLE OF THE DISTAL NEPHRON IN THE REGULATION OF ACID-BASE-EQUILIBRIUM BY THE KIDNEY
Autore:
MALNIC G; FERNANDEZ R; LOPES MJ;
Indirizzi:
UNIV SAO PAULO,INST CIENCIAS BIOMED,DEPT FISIOL & BIOFIS BR-05508900 SAO PAULO SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 4, volume: 27, anno: 1994,
pagine: 831 - 850
SICI:
0100-879X(1994)27:4<831:TROTDN>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY COLLECTING DUCT; NA+-H+ EXCHANGER; RENAL BICARBONATE REABSORPTION; NEM-SENSITIVE ATPASE; PROTON PUMP; RAT-KIDNEY; K-ATPASE; ADENOSINE-TRIPHOSPHATASE; POTASSIUM ABSORPTION; INTERCALATED CELLS;
Keywords:
ACIDIFICATION; BICARBONATE; INTERCALATED CELLS; HA+/K+ATPASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
G. Malnic et al., "THE ROLE OF THE DISTAL NEPHRON IN THE REGULATION OF ACID-BASE-EQUILIBRIUM BY THE KIDNEY", Brazilian journal of medical and biological research, 27(4), 1994, pp. 831-850

Abstract

The present paper reviews mechanisms by which the kidney controls systemic acid-base balance, with emphasis on the role of the distal nephron, and particularly of the cortical distal tubule. These mechanisms are essentially based on H-ion transport along the whole nephron. In proximal tubule cells, approximately 80% of H-ion secretion is mediated by Na/H+ exchange, and 20% by H+-ATPase. In the distal nephron, acid-base transport mechanisms are located mainly in intercalated cells. H-ion secretion is effected by vacuolar H+-ATPase in alpha-intercalated cells and, in K-depleted animals, also by the gastric type H/K ATPase. In animals in alkalosis, beta-intercalated cells secrete bicarbonate by an apical Cl-/HCO3- exchanger, while a basolateral H-ATPase transfers H-ions into the interstitium. In cortical distal tubule, these mechanisms have been shown to be present in the intercalated cells of the connecting segment and of the initial collecting duct (the late distal tubule of micropuncture experiments). In the convoluted distal tubule (early distal tubule), most H-ion secretion occurs by means of the Na/H+ exchanger. These data show that the distal nephron, including the cortical distal tubule, is a nephron segment responsible for a sizeableportion of bicarbonate reabsorption and titratable acid generation, as well as for bicarbonate secretion under appropriate metabolic conditions, being therefore the site of fine regulation of renal mechanisms that maintain acid-base homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:53:40