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Titolo:
EFFECT OF DIPFLUZINE ON PLATELET-AGGREGATION AND THROMBUS FORMATION
Autore:
WANG YL; HE RR;
Indirizzi:
HEBEI MED COLL,DEPT PHARMACOL SHIJIAZHUANG 050017 PEOPLES R CHINA HEBEI MED COLL,DEPT PHYSIOL SHIJIAZHUANG 050017 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 5, volume: 15, anno: 1994,
pagine: 443 - 446
SICI:
0253-9756(1994)15:5<443:EODOPA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Keywords:
DIPFLUZINE; CINNARIZINE; PLATELET AGGREGATION; THROMBOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
Y.L. Wang e R.R. He, "EFFECT OF DIPFLUZINE ON PLATELET-AGGREGATION AND THROMBUS FORMATION", Zhongguo yaoli xuebao, 15(5), 1994, pp. 443-446

Abstract

Dipfluzine (Dip) is a novel diphenylpiperazine calcium channel blocker first synthesized in China. Effects of Dip on experimental thrombosis and platelet aggregation were studied in vitro and in vivo compared with cinnarizine (Cin). Dip 1 and 2 mg.kg(-1) iv and incubated in 1-100 mu mol.L(-1) in vitro inhibited dose- or concentration-dependent rabbit platelet aggregation induced by ADP and by arachidonic acid (AA), respectively. Dip 2.5-10 mg.kg(-1) iv and 50-100 mg.kg(-1) ip inhibited the thrombosis in rats. Dip 10 mg.kg(-1) iv and 200 mu mol.L(-1) depressed the in vitro thrombosis. These results suggest that attenuationof disturbed platelet-vessel wall reaction associated with platelet activation and vasoconstriction may be a main factor involved in the antithrombotic action of Dip, and that the effects of Dip were more potent than those of Cin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/11/18 alle ore 04:03:26