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Titolo:
DIET-INDUCED ATHEROSCLEROSIS IN MICE HETEROZYGOUS AND HOMOZYGOUS FOR APOLIPOPROTEIN-E GENE DISRUPTION
Autore:
ZHANG SH; REDDICK RL; BURKEY B; MAEDA N;
Indirizzi:
UNIV N CAROLINA,SCH MED,DEPT PATHOL,CB 7525,BRINKHOUS BULLITT CHAPEL HILL NC 27599 UNIV N CAROLINA,SCH MED,DEPT PATHOL CHAPEL HILL NC 27599 SANDOZ INC,RES INST E HANOVER NJ 07936
Titolo Testata:
The Journal of clinical investigation
fascicolo: 3, volume: 94, anno: 1994,
pagine: 937 - 945
SICI:
0021-9738(1994)94:3<937:DAIMHA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
E DEFICIENCY; LIPOPROTEIN METABOLISM; E POLYMORPHISM; CHOLESTEROL; ATHEROGENESIS; HYPERCHOLESTEROLEMIA; RABBITS; MODEL;
Keywords:
HIGH-FAT, HIGH-CHOLESTEROL DIET; GENE TARGETING; MACROPHAGE; HYPERCHOLESTEROLEMIA; APO E-DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Zhang et al., "DIET-INDUCED ATHEROSCLEROSIS IN MICE HETEROZYGOUS AND HOMOZYGOUS FOR APOLIPOPROTEIN-E GENE DISRUPTION", The Journal of clinical investigation, 94(3), 1994, pp. 937-945

Abstract

With the aim of establishing whether a genetically reduced capabilityof producing apolipoprotein E (ape E) can affect atherogenesis, we have compared the consequences of dietary stress on normal mice and on mice heterozygous or homozygous for a disrupted apo E gene. A dramatically accelerated development of lesions occurred in the vasculature of the homozygous mutants as a result of feeding an atherogenic diet for 12 wk, and extensive deposition of lipid-filled macrophages was found outside the cardiovascular system. In nine heterozygotes fed the atherogenic diet for 12 wk, the amount of apo E in their total plasma lipoproteins increased to a level comparable to normal, but all nine developed much larger foam cell lesions in their proximal aorta than those found in 3 of 9 normal mice fed the same diet. The other six normals had no lesions. Our study demonstrates that heterozygous mice with only one functional apo E gene are more susceptible to diet-induced atherosclerosis than are normal, two-copy mice. Genetically determined quantitative limitations of apo E could, therefore, have similar effects in humans when they are stressed by an atherogenic diet.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:19:07