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Titolo:
PLASMA-LEVELS OF BENPERIDOL, PROLACTIN, AND HOMOVANILLIC-ACID AFTER INTRAVENOUS VERSUS 2 DIFFERENT KINDS OF ORAL APPLICATION OF THE NEUROLEPTIC IN SCHIZOPHRENIC-PATIENTS
Autore:
SEILER W; WETZEL H; HILLERT A; SCHOLLNHAMMER G; BENKERT O; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55101 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55101 MAINZ GERMANY TROPONWERKE GMBH & CO KG,DEPT MED W-5000 COLOGNE GERMANY
Titolo Testata:
Experimental and clinical endocrinology
fascicolo: 4, volume: 102, anno: 1994,
pagine: 326 - 333
SICI:
0232-7384(1994)102:4<326:POBPAH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ELECTROCHEMICAL DETECTION; HALOPERIDOL TREATMENT; DOPAMINE; RECEPTOR; LACTOTROPHS; HORMONE; RELEASE; DRUGS;
Keywords:
PROLACTIN; NEUROLEPTICS; BENPERIDOL; HOMOVANILLIC ACID; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
W. Seiler et al., "PLASMA-LEVELS OF BENPERIDOL, PROLACTIN, AND HOMOVANILLIC-ACID AFTER INTRAVENOUS VERSUS 2 DIFFERENT KINDS OF ORAL APPLICATION OF THE NEUROLEPTIC IN SCHIZOPHRENIC-PATIENTS", Experimental and clinical endocrinology, 102(4), 1994, pp. 326-333

Abstract

Plasma levels of prolactin (PRL) and the butyrophenone neuroleptic benperidol (BPD) were closely followed 0 to 48 h after acute applicationof 6 mg BPD as intravenous injection, orally as liquid, and orally astablets in 12 schizophrenic patients using a partially randomized cross over design. Drug concentrations showed application specific pharmacokinetic behavior with complete elimination within 48 h. All three applications led to a biphasic PRL response with pronounced initial plasma PRL peaks returning to baseline levels within 48 h. The results suggest that after acute neuroleptic challenge BPD plasma levels as low as 2-3 ng/ml can be sufficient for complete depletion of pituitary PRL stores This initial peak was followed by a PRL plateau about twice above pretreatment values indicating doubling of the PRL synthesis and secretion independent of supraeffective actual BPD concentrations. The PRL plateau persisted as long as BPD concentrations were above those levels which triggered the initial PRL response. As compared with the time of maximum concentrations (t(max)) for BPD, the PRL t(max) was later after iv injection, equal after liquid application, and earlier after tablet administration leading to pronounced application specific differences in shape, direction, and position of resulting hysteresis curves. Plasma levels of homovanillic acid (HVA) were not affected by BPDtreatment. The PRL and HVA levels registered after acute doses of BPDindicated that the hormone responses were most likely the result of acute depletion of PRL stores and subsequent stimulation of hormone synthesis whereas it seemed unlikely that dopaminergic activities were relevant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:41:20