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Titolo:
CARDIOVASCULAR EFFECTS OF 20 DAYS BED REST IN HEALTHY-YOUNG SUBJECTS
Autore:
TAKENAKA K; SUZUKI Y; KAWAKUBO K; HARUNA Y; YANAGIBORI R; KASHIHARA H; IGARASHI T; WATANABE F; OMATA M; BONDEPETERSEN F; GUNJI A;
Indirizzi:
UNIV TOKYO,FAC MED,DEPT LAB MED TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT HLTH ADM TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT INTERNAL MED 2 TOKYO 113 JAPAN EUROPEAN SPACE AGCY,EUROPEAN ASTRONAUTS CTR,MED SUPPORT SECT COLOGNE GERMANY
Titolo Testata:
Acta Physiologica Scandinavica
, volume: 150, anno: 1994, supplemento:, 616
pagine: 59 - 63
SICI:
0001-6772(1994)150:<59:CEO2DB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Keywords:
BED REST; CEREBRAL BLOOD FLOW; DOPPLER ULTRASOUND; ECHOCARDIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
K. Takenaka et al., "CARDIOVASCULAR EFFECTS OF 20 DAYS BED REST IN HEALTHY-YOUNG SUBJECTS", Acta Physiologica Scandinavica, 150, 1994, pp. 59-63

Abstract

To evaluate the effects of inactivity on the cardiovascular system innormal subjects, left ventricular echocardiography and vascular ultrasound of the common carotid artery, abdominal aorta and femoral artery, and lower body negative pressure tests were performed in 14 healthy volunteers (mean age: 22 years) before and after 20 days of strict bedrest. Cardiac output was calculated from echocardiographic measurements and peripheral arterial flows by multiplying cross-sectional area of an artery by heart rate and time-velocity integral measured by pulsed Doppler ultrasound with angle correction. Systemic vascular resistance, lower body vascular resistance, leg vascular resistance and head vascular resistance were also calculated. After bed rest, heart rate increased (69+/-2 to 79+/-3 bpm), while left ventricular diastolic dimension (49+/-1 to 45+/-1 mm), systolic blood pressure (137+/-5 to 116+/-4 mmHg), cardiac output (6.2+/-0.3 to 5.4+/-0.3 1.min-1), abdominal aortic flow (4.1+/-0.4 to 3.1+/-0.3 l.min-1), femoral artery flow (0.66+/-0.07 to 0.33+/-0.04 l.min-1), and lower body negative pressure test tolerance time (750+/-71 to 582+/-48 s) decreased significantly (p<0.05). However, common carotid artery flow (0.97+/-0.09 to 1.03+/-0.08 1.min-1) did not change. Although no significant changes in systemic vascular resistance, lower body vascular resistance or head vascular resistance were observed, leg vascular resistance increased significantly after 20 days of bed rest (6933+/-2905 to 13221+/-2606 dyn.s.cm-1) (p<0.05). In conclusion, 20 days of bed rest increased heart rate, decreased left ventricular size and cardiac output, and caused orthostatic intolerance. However, cerebral blood flow is maintained at the expense of blood flow to the lower body.

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Documento generato il 26/09/20 alle ore 05:23:44