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Titolo:
CARBOHYDRATE AND LIPID-METABOLISM AFTER 20 DAYS OF BED REST
Autore:
YANAGIBORI R; SUZUKI Y; KAWAKUBO K; MAKITA Y; GUNJI A;
Indirizzi:
UNIV TOKYO,DEPT HLTH ADM TOKYO 113 JAPAN MAKITA GEN HOSP TOKYO JAPAN
Titolo Testata:
Acta Physiologica Scandinavica
, volume: 150, anno: 1994, supplemento:, 616
pagine: 51 - 57
SICI:
0001-6772(1994)150:<51:CALA2D>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; INSULIN ACTION; EXERCISE; MEN;
Keywords:
BLOOD GLUCOSE; PHYSICAL INACTIVITY; PLASMA APOLIPOPROTEIN; PLASMA INSULIN; PLASMA LIPIDS; PLASMA LIPOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
R. Yanagibori et al., "CARBOHYDRATE AND LIPID-METABOLISM AFTER 20 DAYS OF BED REST", Acta Physiologica Scandinavica, 150, 1994, pp. 51-57

Abstract

To test the hypothesis that physical inactivity affects carbohydrate and lipid metabolism, we studied the influence of 20 days bed rest in 14 young subjects (9 men and 5 women). There were no changes in body weight or estimated per cent body fat after 20 days bed rest. Total cholesterol, triglyceride, high density lipoprotein cholesterol, and apolipoprotein B levels did not change statistically during bed rest. But apolipoprotein AI levels were significantly lower during and immediately after bed rest compared with control values (p<0.05). On the 3rd day of bed rest a decrease was found in high density lipoprotein-2 cholesterol (p<0.05) and an increase in high density lipoprotein-3 cholesterol (p<0.01) compared with control level. To evaluate the carbohydratemetabolism, each subject underwent a 75g oral glucose tolerance test. The glucose concentrations in response to glucose ingestion did not change during bed rest, but insulin concentrations increased. The insulin-response curve to glucose ingestion tended to shift to the right during bed rest. From the 3rd day of bed rest an increase (p<0.05) of total insulin and a decrease (p<0.05) in blood glucose/insulin ratio were found during the glucose tolerance test which suggested a decrease in insulin sensitivity. These results suggested that physical inactivity impaired carbohydrate- and lipid metabolism.

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Documento generato il 26/09/20 alle ore 05:16:16