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Titolo:
EVIDENCE THAT THE VECTORIAL COMPETENCE OF PHLEBOTOMINE SAND FLIES FORDIFFERENT SPECIES OF LEISHMANIA IS CONTROLLED BY STRUCTURAL POLYMORPHISMS IN THE SURFACE LIPOPHOSPHOGLYCAN
Autore:
PIMENTA PFP; SARAIVA EMB; ROWTON E; MODI GB; GARRAWAY LA; BEVERLEY SM; TURCO SJ; SACKS DL;
Indirizzi:
NIAID,IMMUNOL & CELL BIOL SECT,PARASIT DIS LAB,9000 ROCKVILLE PIKE BETHESDA MD 20892 NIAID,IMMUNOL & CELL BIOL SECT,PARASIT DIS LAB BETHESDA MD 20892 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL WASHINGTON DC 20307 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL BOSTON MA 02115 UNIV KENTUCKY,MED CTR,DEPT BIOCHEM LEXINGTON KY 40536
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 19, volume: 91, anno: 1994,
pagine: 9155 - 9159
SICI:
0027-8424(1994)91:19<9155:ETTVCO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DONOVANI LIPOPHOSPHOGLYCAN; GLYCOCONJUGATE; PAPATASI; MIDGUT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
P.F.P. Pimenta et al., "EVIDENCE THAT THE VECTORIAL COMPETENCE OF PHLEBOTOMINE SAND FLIES FORDIFFERENT SPECIES OF LEISHMANIA IS CONTROLLED BY STRUCTURAL POLYMORPHISMS IN THE SURFACE LIPOPHOSPHOGLYCAN", Proceedings of the National Academy of Sciences of the United Statesof America, 91(19), 1994, pp. 9155-9159

Abstract

Phlebotomine vectors can in some instances transmit only certain species of Leishmania. Comparison of a large number of vector/parasite pairs revealed that species-specific differences in vectorial competence were in every case directly correlated with the ability of promastigotes to attach to the sand-fly midgut, the variable outcomes of which were controlled by structural polymorphisms in the surface lipophosphoglycan (LPG) of the parasite. The ability of Phlebotomus papatasi to transmit only Leishmania major could be attributed to the unique, highly substituted nature of L. major LPG that provides for multiple terminally exposed beta-linked galactose residues for binding. While the relatively unsubstituted LPGs of other Leishmania species were unable to mediate promastigote attachment to P. papatasi, they could mediate binding to midguts of Phlebotomus argentipes, which was found to be a potentially competent vector for every Leishmania species examined. The data suggest that at least some phlebotomine vectors differ with respect to the parasite recognition sites which they express and that midgut adhesion is a sufficiently critical component of vectorial competence as to provide the evolutionary drive for LPG structural polymorphisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:11:57