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Titolo:
A TARGETED CHAIN-TERMINATION MUTATION IN THE MOUSE APC GENE RESULTS IN MULTIPLE INTESTINAL TUMORS
Autore:
FODDE R; EDELMANN W; YANG K; VANLEEUWEN C; CARLSON C; RENAULT B; BREUKEL C; ALT E; LIPKIN M; KHAN PM; KUCHERLAPATI R;
Indirizzi:
LEIDEN UNIV,DEPT GENET 2333 AL LEIDEN NETHERLANDS YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOLEC GENET BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL BRONX NY 10461 MEM SLOAN KETTERING CANC CTR NEW YORK NY 10021
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 19, volume: 91, anno: 1994,
pagine: 8969 - 8973
SICI:
0027-8424(1994)91:19<8969:ATCMIT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; GERM-LINE MUTATIONS; COLORECTAL TUMORIGENESIS; SOMATIC MUTATIONS; CANCER; IDENTIFICATION; NEOPLASIA; FAP; ASSOCIATION; PROTEIN;
Keywords:
GENE TARGETING; COLORECTAL CANCER; ANIMAL MODEL FOR HUMAN DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
R. Fodde et al., "A TARGETED CHAIN-TERMINATION MUTATION IN THE MOUSE APC GENE RESULTS IN MULTIPLE INTESTINAL TUMORS", Proceedings of the National Academy of Sciences of the United Statesof America, 91(19), 1994, pp. 8969-8973

Abstract

Germ line mutations in the human adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis, an autosomal dominant disorder characterized by the early onset of multiple adenomatous polyps in the large bowel with a high likelihood of developing colorectal carcinomas. To understand the role of APC in intestinal tumor formation, we have introduced a chain-termination mutation in the 15th exon of themouse Apc gene and employed it to modify the endogenous gene by homologous recombination in embryonic stem cells. Mice which are heterozygous for the Apc gene modification progressively develop intestinal tumors in a manner that is similar to that observed in patients with familial adenomatous polyposis and in mice which carry a mutation called multiple intestinal neoplasia (Min). Our results indicate that the Apc gene modification is a critical event in the initiation of intestinal tumor formation and results in an autosomal dominant predisposition toward development of spontaneous colonic and intestinal tumors in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:49:07