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Titolo:
NECROSIS IN PONTINE GLIOMAS - RADIATION-INDUCED OR NATURAL-HISTORY
Autore:
NELSON MD; SONI D; BARAM TZ;
Indirizzi:
CHILDRENS HOSP LOS ANGELES,DEPT RADIOL,4650 SUNSET BLVD LOS ANGELES CA 90027 CHILDRENS HOSP LOS ANGELES,DEPT RADIAT THERAPY LOS ANGELES CA 90027 CHILDRENS HOSP LOS ANGELES,DIV NEUROL LOS ANGELES CA 90027 UNIV SO CALIF,DEPT NEUROL LOS ANGELES CA 90089
Titolo Testata:
Radiology
fascicolo: 1, volume: 191, anno: 1994,
pagine: 279 - 282
SICI:
0033-8419(1994)191:1<279:NIPG-R>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM GLIOMAS; PEDIATRIC-ONCOLOGY-GROUP; HYPERFRACTIONATED RADIOTHERAPY; PROGNOSTIC FACTORS; TUMORS; CHILDREN; PET;
Keywords:
BRAIN STEM, NEOPLASMS; CHILDREN, CENTRAL NERVOUS SYSTEM; NEOPLASMS, THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Nelson et al., "NECROSIS IN PONTINE GLIOMAS - RADIATION-INDUCED OR NATURAL-HISTORY", Radiology, 191(1), 1994, pp. 279-282

Abstract

PURPOSE: To determine whether the central necrotic lesions that develop in a large number of patients with pontine gliomas are secondary toradiation therapy, specifically high-dose (7,200-7,800 cGy) hyperfractionation radiation therapy, or are part of the biologic progression of this tumor. MATERIALS AND METHODS: The authors analyzed neuroimagingstudies of 31 consecutive patients with pontine-centered gliomas and assessed the time of onset of necrosis, the type and dose of radiationtherapy administered, and the length of survival. RESULTS: Necrosis was present at diagnosis in eight of the 31 patients (26%). Time to appearance and total prevalence of central necrosis did not differ in thestandard versus hyperfractionated therapy groups. The time between diagnosis and the appearance of necrosis correlated with length of survival (P = .005, Kendall correlation). CONCLUSION. In a substantial number of patients, central necrosis in pontine gliomas is not caused by radiation therapy but is an indication of an advanced tumor stage. Children with central necrosis at diagnosis have a significantly shorter median survival than do those without, regardless of the type of therapy administered.

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Documento generato il 15/07/20 alle ore 19:43:55