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Titolo:
KALLMAN SYNDROME VERSUS IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM AT MR-IMAGING
Autore:
VOGL TJ; STEMMLER J; HEYE B; SCHOPOHL J; DANEK A; BERGMAN C; BALZER JO; FELIX R;
Indirizzi:
FREE UNIV BERLIN,CLIN RUDOLF VIRCHOW,DEPT RADIOL,AUGUSTENBURGERPLATZ 1 D-13353 BERLIN GERMANY UNIV MUNICH,DEPT PEDIAT GENET W-8000 MUNICH 2 GERMANY UNIV MUNICH,DEPT INTERNAL MED W-8000 MUNICH 2 GERMANY UNIV MUNICH,DEPT NEUROL W-8000 MUNICH 2 GERMANY
Titolo Testata:
Radiology
fascicolo: 1, volume: 191, anno: 1994,
pagine: 53 - 57
SICI:
0033-8419(1994)191:1<53:KSVIHH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC HYPOGONADISM; ANOSMIA; GENE; MOLECULES; ADHESION;
Keywords:
BRAIN, ABNORMALITIES; NERVES, CRANIAL; HYPOTHALAMUS; PARANASAL SINUSES, ABNORMALITIES; TESTIS, ABNORMALITIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Vogl et al., "KALLMAN SYNDROME VERSUS IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM AT MR-IMAGING", Radiology, 191(1), 1994, pp. 53-57

Abstract

PURPOSE: To identify morphologic differences between Kallman syndrome(KS) and idiopathic hypogonadotropic hypogonadism (IHH) and establisha role for magnetic resonance (MR) imaging in these disorders. MATERIALS AND METHODS: Twenty-eight patients were compared with 10 eugonal male volunteers. Eighteen patients had KS (hypogonadotropic hypogonadism with anosmia) and 10 had IHH. All participants underwent hormone analysis, a sniff-bottle smell test, and gadolinium-enhanced MR imaging. Changes in the hypothalamic-hypophyseal region and the rhinencephalon were evaluated. RESULTS: MR imaging revealed intracranial morphologic changes in all patients on plain T1-weighted sections. Seventeen patients with KS demonstrated aplasia of an olfactory bulb; one olfactory sulcus was absent in six, rudimentary in four, and normal in eight. Olfactory bulbs were present in all 10 IHH patients and three showed one slightly hypoplastic bulb. Ten patients with KS and three with IHH showed an enlarged paranasal sinus system. Further MR findings were similar. CONCLUSION: MR imaging demonstrates abnormalities of the rhinencephalon present in KS patients and occasionally absent in IHH patients.

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Documento generato il 04/12/20 alle ore 23:44:18