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Titolo:
PHARMACOTHERAPY OF THE DEPRESSED PATIENT WITH CARDIOVASCULAR AND OR CEREBROVASCULAR ILLNESS/
Autore:
LANE RM; SWEENEY M; HENRY JA;
Indirizzi:
PFIZER INC,INT PHARMACEUT GRP,235 E 42ND ST NEW YORK NY 10017 PFIZER LTD,DEPT MED SANDWICH KENT ENGLAND GUYS HOSP,POISONS UNIT LONDON SE1 9RT ENGLAND
Titolo Testata:
British journal of clinical practice
fascicolo: 5, volume: 48, anno: 1994,
pagine: 256 - 262
SICI:
0007-0947(1994)48:5<256:POTDPW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARRHYTHMIA SUPPRESSION TRIAL; PSYCHOTROPIC-DRUG USE; PHARMACOKINETIC PROPERTIES; MYOCARDIAL-INFARCTION; TRICYCLIC ANTIDEPRESSANTS; THERAPEUTIC EFFICACY; REUPTAKE INHIBITORS; GENERAL-POPULATION; MEDICALLY ILL; HEART-DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
113
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Lane et al., "PHARMACOTHERAPY OF THE DEPRESSED PATIENT WITH CARDIOVASCULAR AND OR CEREBROVASCULAR ILLNESS/", British journal of clinical practice, 48(5), 1994, pp. 256-262

Abstract

Cardiovascular and cerebrovascular disease are associated with a highincidence of depressive disorder. Despite this high level of co-morbidity, depressive disorders appear to go largely unrecognised and remain untreated. This may have serious consequences, as concomitant depression worsens the prognosis in patients with cardiovascular or cerebrovascular disease, increases medical costs, and delays return to work. Treatment with traditional tricyclic antidepressants is difficult in these patients because of the known cardiac effects. The favourable side-effect profiles of the 5-HT reuptake inhibitors suggest that they mayoffer therapeutic advantages, as they have little or no effect on cardiac conduction, do not cause orthostatic hypotension, and lack serious sequelae in overdose. The pharmacological profiles and the reduced potential of these newer antidepressant drugs to cause drug interactionshow important differences that may be of clinical relevance in this patient population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 12:57:48