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Titolo:
COMBINED SEGREGATION AND LINKAGE ANALYSIS OF GRAVES-DISEASE WITH A THYROID AUTOANTIBODY DIATHESIS
Autore:
SHIELDS DC; RATANACHAIYAVONG S; MCGREGOR AM; COLLINS A; MORTON NE;
Indirizzi:
UNIV DUBLIN TRINITY COLL,DEPT GENET DUBLIN 2 IRELAND UNIV SOUTHAMPTON,PRINCESS ANNE HOSP,DEPT CHILD HLTH,CRC,GENET EPIDEMIOL RES GRP SOUTHAMPTON HANTS ENGLAND UNIV LONDON KINGS COLL,SCH MED,DEPT MED LONDON WC2R 2LS ENGLAND PRINCE SONGKLA UNIV,DEPT MED & BIOMED SCI SONGKHLA THAILAND
Titolo Testata:
American journal of human genetics
fascicolo: 3, volume: 55, anno: 1994,
pagine: 540 - 554
SICI:
0002-9297(1994)55:3<540:CSALAO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOD SCORE; MODELS; HLA; INHERITANCE; ANTIGENS; GENETICS; FAMILIES; TRAITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Shields et al., "COMBINED SEGREGATION AND LINKAGE ANALYSIS OF GRAVES-DISEASE WITH A THYROID AUTOANTIBODY DIATHESIS", American journal of human genetics, 55(3), 1994, pp. 540-554

Abstract

Combined segregation and linkage analysis is a powerful technique formodeling linkage to diseases whose etiology is more complex than the effect of a well-described single genetic locus and for investigating the influence of single genes on various aspects of the disease phenotype. Graves disease is familial and is associated with human leukocyteantigen (HLA) allele DR3. Probands with Graves disease, as well as close relatives, have raised levels of thyroid autoantibodies. This phenotypic information additional to affection status may be considered bythe computer program COMDS for combined segregation and linkage analysis, when normals are classified into diathesis classes of increasing thyroid autoantibody titer. The ordinal model considers the cumulativeodds of lying in successive classes, and a single additional parameter is introduced for each gene modeled. Distributional assumptions are avoided by providing estimates of the population frequencies of each class. Evidence for linkage was increased by considering the thyroid autoantibody diathesis and by testing two-locus models. The analysis revealed evidence for linkage to HLA-DR when the strong coupling of the linked locus to allele DR3 was considered (led score of 6.6). Linkage analysis of the residual variation revealed no evidence of linkage to Gm, but a suggestion of linkage to Km.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:40:04