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Titolo:
HIV-1 ENTRY AND REVERSE TRANSCRIPTION IN MACROPHAGES
Autore:
OBRIEN WA;
Indirizzi:
W LOS ANGELES VET AFFAIRS MED CTR,DEPT MED,WILSHIRE & SAWTELLE BLVD,691-111F LOS ANGELES CA 90073 UNIV CALIF LOS ANGELES LOS ANGELES CA 00000
Titolo Testata:
Journal of leukocyte biology
fascicolo: 3, volume: 56, anno: 1994,
pagine: 273 - 277
SICI:
0741-5400(1994)56:3<273:HEARTI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; RECOMBINANT SOLUBLE CD4; AIDS-RELATED COMPLEX; ENVELOPE V3 LOOP; T-CELLS; MONONUCLEAR PHAGOCYTES; GLYCOPROTEIN GP120; HUMAN MONOCYTES; TYPE-1 VIRIONS; HTLV-III/LAV;
Keywords:
CD4; GP120; ENVELOPE; NEUTRALIZATION; NUCLEOTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Obrien, "HIV-1 ENTRY AND REVERSE TRANSCRIPTION IN MACROPHAGES", Journal of leukocyte biology, 56(3), 1994, pp. 273-277

Abstract

Although CD4 is required for efficient virus entry, it is not sufficient for entry of all primary HIV-1 strains. There may be additional virus-cell interactions, possibly involving the V3 region of the extracellular envelope protein, gp120, that occur following conformational changes induced by CD4 binding. This second interaction would precede fusion events and entry of the virus core. Primary HIV-1 strains appear to have a higher virion envelope density and retain gp120 better than HIV-1 strains adapted to growth in T cell lines in culture. These properties may confer a growth advantage in vivo to primary strains on thebasis of less well exposed CD4 binding and neutralization domains. HIV-1 entry into both activated and quiescent T cells, as well as macrophages, is efficient for most primary strains, but there are different patterns of reverse transcription. Productive infection of activated Tcells is associated with cell proliferation and accumulation of full-length reverse transcripts within 4 to 6 h. In resting, nondividing T cells, reverse transcription is aborted prior to full-length viral DNAformation. A third pattern of reverse transcription is seen in nondividing cultured macrophages with slow kinetics and accumulation of full-length viral DNA between 36 and 48 h. This rate can be increased by adding exogenous nucleotides, but still not to the rate seen in activated T cells. Future antiretroviral therapies may involve interference with cell-specific functions involved in reverse transcription.

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Documento generato il 01/12/20 alle ore 10:58:39