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Titolo:
CHANGES IN BRAIN MAO ACTIVITY AND GLYCOGEN LEVELS UPON CHRONIC ALCOHOLIZATION OF 3 SUCCESSIVE GENERATIONS OF RATS
Autore:
NEVO I; PARVEZ S;
Indirizzi:
CHU PITIE SALPETRIERE,INSERM,U288,91 BLVD HOP F-75634 PARIS 13 FRANCE UNIV PARIS 11,NEUROPHARMACOL UNIT F-91405 ORSAY FRANCE
Titolo Testata:
Fundamental and clinical pharmacology
fascicolo: 4, volume: 8, anno: 1994,
pagine: 347 - 355
SICI:
0767-3981(1994)8:4<347:CIBMAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE ACTIVITY; CHRONIC ETHANOL; FRONTAL-CORTEX; PLATELET; NEURONS; PATHWAY; TISSUE; LINES;
Keywords:
ETHANOL; ALCOHOLISM; MONOAMINE OXIDASE; MAO; GLUCOSE; GLYCOGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
I. Nevo e S. Parvez, "CHANGES IN BRAIN MAO ACTIVITY AND GLYCOGEN LEVELS UPON CHRONIC ALCOHOLIZATION OF 3 SUCCESSIVE GENERATIONS OF RATS", Fundamental and clinical pharmacology, 8(4), 1994, pp. 347-355

Abstract

Changes in neurobiological parameters were examined from early life (10 days post-natal) until late adulthood (8 months post-natal) in three successive generations of alcoholized rats. The mean daily consumption of alcohol by the 2nd and 3rd generation rats (7.40 +/- 0.22 and 7.70 +/- 0.20 g ethanol/kg body weight, respectively) was significantly greater than that of the 1st generation alcoholized group (4.26 +/- 0.33 g/kg). Brain/body weight ratios of alcoholized rats, 10 days post-natal, were significantly greater than controls, with Ist generation alcoholized rats presenting significantly greater brain/body weight ratios than those of the 2nd or 3rd generation, which tended toward control weights and ratios. This difference between alcoholized rats and controls persisted, although to a lesser extent, at 8 months post-natal. Glycogen content in the brains of rats of all alcoholized generations was significantly lower than in controls at 10 days post-natal, with areversal of this situation in later life for 2nd and 3rd generation rats, which presented significantly greater cerebral glycogen levels than control or Ist generation alcoholized rats (which had an equivalentcerebral glycogen content). In 10-day-old rat pups, monoamine oxidase(MAO) activity in brain tissues had a tendency (mostly non-significant) to be greater in alcoholized rats than in controls, with a reversalof this situation, ie a statistically significant decrease in MAO activity in the 2nd and 3rd alcoholized generations with respect to controls, in g-month-old rats. MAO activity in adrenal glands of alcoholized rats was greater than in controls at 10 days post-natal, and this difference persisted at 8 months.

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Documento generato il 14/08/20 alle ore 16:57:01