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Titolo:
THE NUMBER AND SIZE OF GLOMERULI IN LONG-TERM LITHIUM-INDUCED NEPHROPATHY IN RATS
Autore:
NYENGAARD JR; BENDTSEN TF; CHRISTENSEN S; OTTOSEN PD;
Indirizzi:
RANDERS CENT SYGEHUS,INST PATHOL DK-8900 RANDERS DENMARK RANDERS CENT SYGEHUS,INST PATHOL DK-8900 RANDERS DENMARK AARHUS UNIV,INST PATHOL,STEREOL RES LAB DK-8000 AARHUS DENMARK AARHUS UNIV,INTERNAL MED CLIN 2,INST EXPTL CLIN RES AARHUS DENMARK UNIV COPENHAGEN,DEPT PHARMACOL COPENHAGEN DENMARK
Titolo Testata:
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica
fascicolo: 1, volume: 102, anno: 1994,
pagine: 59 - 66
SICI:
0903-4641(1994)102:1<59:TNASOG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; ATUBULAR GLOMERULI; ARBITRARY PARTICLES; STRUCTURAL-CHANGES; INTERSTITIAL NEPHROPATHY; STEREOLOGICAL ESTIMATION; KIDNEY; VOLUME;
Keywords:
GLOMERULAR NUMBER; GLOMERULAR VOLUME; HYPERFILTRATION; KIDNEY; LITHIUM; STEREOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Nyengaard et al., "THE NUMBER AND SIZE OF GLOMERULI IN LONG-TERM LITHIUM-INDUCED NEPHROPATHY IN RATS", APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 102(1), 1994, pp. 59-66

Abstract

Chronic renal failure was induced in 10 Wistar rats using a lithium-containing (40 mmol/kg) diet from time of birth until an age of 55-65 weeks. Nine Wistar rats served as controls. The plasma lithium, the plasma urea, and the inulin clearance were measured, and one kidney was fixed by vascular perfusion with glutaraldehyde. The number of glomeruli was estimated stereologically by the fractionator method. The total number of glomeruli per kidney was 23.9 x 10(3) +/- 3.65 x 10(3) (+/- SD) in controls and 22.0 x 10(3) +/- 1.48 x 10(3) in the lithium-treated group, showing no statistically significant difference. The mean glomerular volume was also estimated using stereological methods: The number-weighted mean volume was reduced by 42% in the lithium-treated group, whereas the volume-weighted mean volume was unchanged. This can be attributed to the occurrence of many small glomeruli and a few very large glomeruli in the lithium-treated group. The many small glomerulihave in a previous study been shown to be atubular. The present studyshowed that the glomerular population is quite resistant to the deleterious effect of lithium; thus glomerular atrophy was seen, but no loss of glomeruli occurred.

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Documento generato il 04/12/20 alle ore 19:27:29