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Titolo:
IN-VIVO AND IN-VITRO EFFECTS OF ADENOSINE-5'-O-12-THIODIPHOSPHATE) ONPANCREATIC HORMONES IN DOGS
Autore:
HILLAIREBUYS D; GROSS R; PARESHERBUTE N; RIBES G; LOUBATIERESMARIANI MM;
Indirizzi:
FAC MED MONTPELLIER,INST BIOL,PHARMACOL LAB,BD HENRI IV F-34060 MONTPELLIER FRANCE FAC MED MONTPELLIER,PHARMACOL & PHARMACODYNAMIE LAB MONTPELLIER FRANCE HOP LAPEYRONIE,DEPT MALADIES METABOL MONTPELLIER FRANCE
Titolo Testata:
Pancreas
fascicolo: 5, volume: 9, anno: 1994,
pagine: 646 - 651
SICI:
0885-3177(1994)9:5<646:IAIEOA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT PANCREAS; SOMATOSTATIN SECRETION; INSULIN-SECRETION; DIABETIC RATS; VASCULAR BED; GLUCOSE; STIMULATION; ALLOXAN; CELL; ADENOSINE-5'-O-(2-THIODIPHOSPHATE);
Keywords:
PURINERGIC AGENT; ADP-BETA-S; INSULIN SECRETION; SOMATOSTATIN SECRETION; GLUCAGON SECRETION; DOG; ALLOXAN DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D. Hillairebuys et al., "IN-VIVO AND IN-VITRO EFFECTS OF ADENOSINE-5'-O-12-THIODIPHOSPHATE) ONPANCREATIC HORMONES IN DOGS", Pancreas, 9(5), 1994, pp. 646-651

Abstract

Adenosine-5'-0-(2-thiodiphosphate) (ADP beta S), a P-2y purinergic agonist, has been shown to be a potent insulin secretagogue on the isolated rat pancreas. In the present work the effects of ADP beta S on insulin, somatostatin, and glucagon secretions were investigated in dogs. In vivo, in anesthetized fasted dogs, i.v. ADP beta S (0.1 mg kg(-1))induced an immediate increase in insulin and somatostatin-like immunoreactivity (SLI) but not in glucagon pancreaticoduodenal outputs. In conscious fasted dogs, i.v. ADP beta S (0.1 mg kg(-1)) produced an immediate and transient augmentation in plasma insulin levels but not in plasma SLI and glucagon levels. In vitro, the effects of ADP beta S were investigated on the isolated uncinate process of dog pancreas, from normal and alloxan-diabetic animals. In normal uncinate process, in presence of 8.3 mill glucose, ADP beta S (1 mu M) stimulated insulin andSLI releases but not glucagon release. On uncinate process from diabetic animals, ADP beta S (1 mu M) retained its stimulating effects but the responses were impaired as compared with normal dogs: Insulin response was drastically diminished and SLI response strongly enhanced. Inconclusion, ADP beta S is a potent insulin secretory agent in dog. This P-2y purinoceptor agonist, which exerts a direct stimulatory effecton pancreatic SLI, is interestingly devoid of direct glucagonotropic properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:52:27