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Titolo:
LACK OF EFFECT OF CHOLECYSTOKININ RECEPTOR ANTAGONIST (CR1505) ON RECOVERY OF EXPERIMENTAL PANCREATITIS AFTER PANCREATIC DUCT OCCLUSION IN RATS
Autore:
TOMITA H; MIYASAKA K; JIMI A; MISHIMA Y; FUNAKOSHI A;
Indirizzi:
KYUSHU NATL CANC CTR,DEPT GASTROENTEROL,MINAMI KU,NOTAME 3-1-1 FUKUOKA 815 JAPAN KYUSHU NATL CANC CTR,DEPT GASTROENTEROL,MINAMI KU FUKUOKA 815 JAPAN TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT CLIN PHYSIOL TOKYO JAPAN KURUME UNIV,DEPT PATHOL 1 KURUME FUKUOKA 830 JAPAN TOKYO MED & DENT UNIV,DEPT SURG 2 TOKYO 113 JAPAN
Titolo Testata:
Pancreas
fascicolo: 5, volume: 9, anno: 1994,
pagine: 638 - 645
SICI:
0885-3177(1994)9:5<638:LOEOCR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA CHOLECYSTOKININ; MICE; BILE; CCK; L-364,718; LOXIGLUMIDE; INHIBITION; PROGLUMIDE; CERULEIN; BLOCKADE;
Keywords:
CHOLECYSTOKININ; CCK-RECEPTOR ANTAGONIST; PANCREATIC DUCT LIGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
H. Tomita et al., "LACK OF EFFECT OF CHOLECYSTOKININ RECEPTOR ANTAGONIST (CR1505) ON RECOVERY OF EXPERIMENTAL PANCREATITIS AFTER PANCREATIC DUCT OCCLUSION IN RATS", Pancreas, 9(5), 1994, pp. 638-645

Abstract

The effect of long term administration of a synthetic cholecystokinin(CCK) receptor antagonist CR1505 (loxiglumide) on pancreatitis was examined in rats after pancreatic duct ligation (PL) with an internal bile fistula. All rats were given both 6 mg/day of CR1505 continuously infused intraduodenally with an osmotic pump and 32 mg/day introduced into the stomach with an orogastric tube. Rats were killed 7, 14, and 28 days after FL, and changes of body weight, pancreatic wet weight, daily food intake, pancreatic protein content, and histology, plasma amylase concentration, and both plasma and duodenal CCK concentrations were examined. Administration of CR1505 for 7 days from immediately after FL, resulted in decrease of body weight, increase of daily food intake, and significant increases of intestinal CCK concentration and the level of CCK mRNA. However, its administration from day 7 to day 14 or28 did not improve any of the parameters examined except inflammatoryinfiltration of the pancreas on the 14th postoperative day. These results suggest that CR1505 may have a beneficial effect on recovery frompancreatitis when administered during the early stage, but not when administered during a later stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:09:55